EGF, TGF-a, and EGF-R in Human Colorectal Adenocarcinoma
Open accessAbstract
The over-expression of epidermal growth factor receptor (EGF-R), EGF and transforming growth factor alpha (TGFalpha) could be a mechanism for colorectal tumor cells to escape normal growth controls. Our aims were: (i) to evaluate EGF, TGFalpha, and EGF-R concentrations in neoplastic tissue and surrounding mucosa from 40 patients with colorectal adenocarcinoma, and (ii) to assess the expression of these growth factors and their receptor in relation to the tumor site. EGF, TGFalpha, and EGF-R were detected in either colorectal neoplastic tissue or surrounding mucosa. Significantly increased levels of EGF and EGF-R were present in neoplastic samples compared to surrounding mucosa. Furthermore, a significant increase in TGFalpha and in EGF levels was observed in the left-sided surrounding mucosa and left-sided neoplastic tissue, respectively. EGF-R stimulation by its ligands may play an important role in colorectal neoplastic tissue. Moreover, the higher content of growth factors in the left-side than the right-side colon suggests different growth properties in the proximal and distal colon.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
EGFR is activated by multiple ligands, including EGF, TGF-α, HB-EGF, epiregulin and amphiregulin.
“EGFR is part of the EGFR tyrosine kinase family [61] and is activated by multiple ligands, such as EGF, TGF-α, HB-EGF, epiregulin (EREG) and amphiregulin (AREG) [62–64].”
From Resistance to anti-EGFR therapies in metastatic colorectal cancer: underlying mechanisms and reversal strategies (2021) · cites this paper as [63]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 27 · Cited by 251
Research works printed but not linked: 3
- Roncucci L, Scalmati A, Ponz de Leon M. Pattern of cell kinetics in colorectal mucosa of patients with different types of adenomatous polyps of the large bowel. Cancer 1991; 68: 873-8.
- Narisawa T, Takahashi M, Niwa M. Increased mucosal or- nithine decarboxylase activity in large bowel with multiple tumors, adenocarcinoma, and adenoma. Cancer 1989; 63: 1572 -6.
- Stralka DJ, Strobel HW. Cytochrome P-450 activity and distribution in the human colon mucosa. Cancer 1980; 64: 2111 -6.
- Authors
- Messa, C., Russo, F., Gabriella Caruso, M., & Di Leo, A.
- Affiliations
- Gastroenterology Hospital "Saverio de Bellis" (IT)
- Venue
- Acta Oncologica
- Published
- 1998-01
- Volume
- 37
- Issue
- 3
- Pages
- 285-289
- ISSN
- 0284-186X (ISSN-L)
- 1651-226X
- OpenAlex
- W2133453529
- Cited by
- 251
- References
- 27
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 2 · 2023: 6 · 2022: 7 · 2021: 7 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 3 · 2015: 6 · 2014: 3 · 2013: 6 · 2012: 9
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Acta Oncologica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- colorectal adenocarcinoma, epidermal growth factor, transforming growth factor-alpha, epidermal growth factor receptor, tumor microenvironment, left-sided colon, tumor growth control
- MeSH terms
- Adenocarcinoma, Aged, Female, Humans, Intestinal Mucosa, Functional Laterality, Male, Middle Aged, Colorectal Neoplasms, Transforming Growth Factor alpha, ErbB Receptors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
