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Trace Determination of Domoic Acid in Sea Water and Phytoplankton by High-Performance Liquid Chromatography of the Fluorenylmethoxycarbonyl (FMOC) Derivative
Abstract
A method is presented for the trace determination of domoic acid, a neurotoxic amino acid responsible for cases of Amnesic Shellfish Poisoning resulting from the consumption of contaminated shellfish. The method involves pre-column derivatization with 9-fluorenylmethylchloroformate to form the FMOC derivative followed by reversed-phase HPLC with fluorescence detection. The detection limit for domoic acid in seawater and aqueous extracts is 15pg/mL (50 pM) using gradient elution, a 20μL injection volume, and a 2.1mm I.D. microbore column. Use of dihydrokainic acid as an internal standard improved quantitation. The method was applied to the detection of domoic acid in seawater, in phytoplankton cultures (Nitzschia pungens forma multiseries), and in natural mixed phytoplankton assemblages in estuarine waters.
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Cited by
An unprecedented coastwide toxic algal bloom linked to anomalous ocean conditions
McCabe, R. M., Hickey, B. M., Kudela, R. M., Lefebvre, K. A., Adams, N. G., Bill, B. D., Gulland, F. M. D., Thomson, R. E., Cochlan, W. P., & Trainer, V. L. (2016) · Geophysical Research Letters · doi:10.1002/2016gl070023 · Cited by 572
Rapid enzyme-linked immunosorbent assay for detection of the algal toxin domoic acid
Litaker, R. W., Stewart, T. N., Eberhart, B.-T. L., Wekell, J. C., Trainer, V. L., Kudela, R. M., Miller, P. E., Roberts, A., Hertz, C., Johnson, T. A., et al. (2008) · Journal of Shellfish Research · doi:10.2983/0730-8000-27.5.1301 · Cited by 47
Metadata
- Authors
- Pocklington, R., Milley, J. E., Bates, S. S., Bird, C. J., De Freitas, A. S. W., & Quilliam, M. A.
- Venue
- International Journal of Environmental Analytical Chemistry
- Publisher
- Informa UK Limited
- Published
- 1990-03
- Volume
- 38
- Issue
- 3
- Pages
- 351-368
- ISSN
- 0306-7319 (ISSN-L)
- 1029-0397
- OpenAlex
- W2066611423
- Cited by
- 177
- References
- 0
- FWCI
- 7.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Trace Determination of Domoic Acid in Sea Water and Phytoplankton by High-Performance Liquid Chromatography of the Fluorenylmethoxycarbonyl (FMOC) Derivative. https://app.cochat.ai/papers/10.1080/03067319008026940
- The paper
- Pocklington, R., Milley, J. E., Bates, S. S., Bird, C. J., De Freitas, A. S. W., & Quilliam, M. A. (1990). Trace Determination of Domoic Acid in Sea Water and Phytoplankton by High-Performance Liquid Chromatography of the Fluorenylmethoxycarbonyl (FMOC) Derivative. International Journal of Environmental Analytical Chemistry. https://doi.org/10.1080/03067319008026940
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
