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Review and analysis of FDA approved drugs using lipid-based formulations
Open accessAbstract
Lipid-based drug delivery systems (LBDDS) are one of the most studied bioavailability enhancement technologies and are utilized in a number of U.S. Food and Drug Administration (FDA) approved drugs. While researchers have used several general rules of thumb to predict which compounds are likely to benefit from LBDDS, formulation of lipid systems is primarily an empiric endeavor. One of the challenges is that these rules of thumb focus in different areas and are used independently of each other. The Developability Classification System attempts to link physicochemical characteristics with possible formulation strategies. Although it provides a starting point, the formulator still has to empirically develop the formulation. This article provides a review and quantitative analysis of the molecular properties of these approved drugs formulated as lipid systems and starts to build an approach that provides more directed guidance on which type of lipid system is likely to be the best for a particular drug molecule.
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“With numerous commercial successes, lipid-based drug delivery systems (LBDDS) have a proven track record to improve oral absorption of poorly water-soluble drugs (PWSDs) through a variety of mechanisms including increasing solubility, reducing food-induced exposure variability and improving overall intestinal uptake (Savla et al., 2017).”
From Exploring impact of supersaturated lipid-based drug delivery systems of celecoxib on in vitro permeation across PermeapadⓇ membrane and in vivo absorption (2020) · cites this paper as Savla et al., 2017
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Metadata
- Authors
- Savla, R., Browne, J., Plassat, V., Wasan, K. M., & Wasan, E. K.
- Affiliations
- Catalent (United States) (US)
- Cerenis Therapeutics (France) (FR)
- University of Saskatchewan (CA)
- Corresponding author
- Savla, Ronak
- Venue
- Drug Development and Industrial Pharmacy
- Publisher
- Informa UK Limited
- Published
- 2017-07-06
- Volume
- 43
- Issue
- 11
- Pages
- 1743-1758
- ISSN
- 0363-9045 (ISSN-L)
- 1520-5762
- OpenAlex
- W2732877934
- Cited by
- 225
- References
- 75
- Citations by year
- 2026: 12 · 2025: 24 · 2024: 23 · 2023: 23 · 2022: 27 · 2021: 39 · 2020: 42 · 2019: 21 · 2018: 14
- FWCI
- 10.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Drug Development and Industrial Pharmacy (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Figshare (cc-by)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- lipid-based drug delivery, bioavailability enhancement, FDA-approved drugs, physicochemical properties, molecular properties
- MeSH terms
- Biological Availability, Chemistry, Pharmaceutical, Humans, Lipids, United States, Drug Delivery Systems, Drug Approval
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