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Prolonged skin retention of clobetasol propionate by bio-based microemulsions: a potential tool for scalp psoriasis treatment
Open accessAbstract
Novel effective and cosmetically acceptable formulations are needed for the treatment of scalp psoriasis, due to the poor efficacy of the current products. The challenge in developing safe, efficient, and convenient delivery systems for this drug was addressed in the present work by formulating clobetasol propionate-loaded W/O microemulsions (MEs). Pseudo-ternary phase diagrams were constructed by using a combination of biocompatible and biodegradable excipients. Characterization studies demonstrated that selected MEs had suitable technological features such as being Newtonian fluids, possessing low viscosity, and high thermodynamic stability. Photomicrographs showed a significant alteration of the skin structure after treatment with MEs, and a preferential concentration of these in the stratum corneum and epidermis. These data, together with ex vivo permeation results, suggested an enhanced topical targeted effect due to an increased drug retention efficacy in the upper skin layers, as desired. Moreover, the bio-based excipients selected could contribute to the healing of the psoriatic scalp. In this way, the improvement of clobetasol efficacy is combined with the useful properties of the microemulsion components and with environmental safety.
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“In the present literature there is some confusion regarding the classification of NEs because they are sometimes confused with microemulsions, which are thermodynamically stable systems that form spontaneously [24,46].”
From Nanoemulsions for “Nose-to-Brain” Drug Delivery (2019) · cites this paper as [46]
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Cited by
Sorted by citations
Nanoemulsions for “Nose-to-Brain” Drug Delivery
Bonferoni, M. C., Rossi, S., Sandri, G., Ferrari, F., Gavini, E., Rassu, G., & Giunchedi, P. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11020084 · Cited by 269
Self-citation
Metadata
- Authors
- Langasco, R., Tanrıverdi, S. T., Özer, Ö., Roldo, M., Cossu, M., Rassu, G., Giunchedi, P., & Gavini, E.
- Affiliations
- University of Sassari (IT)
- Ege University (TR)
- University of Portsmouth (GB)
- Corresponding author
- Gavini, Elisabetta
- ORCID
- Venue
- Drug Development and Industrial Pharmacy
- Publisher
- Informa UK Limited
- Published
- 2017-11-08
- Volume
- 44
- Issue
- 3
- Pages
- 398-406
- ISSN
- 0363-9045 (ISSN-L)
- 1520-5762
- OpenAlex
- W2766740795
- Cited by
- 25
- References
- 62
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 2
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- cc-by
- Locations
- Drug Development and Industrial Pharmacy (publishedVersion)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- UnissResearch (Università degli Studi di Sassari) (submittedVersion)
- Figshare (cc-by)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Surfactants and Colloidal Systems
- Keywords
- clobetasol propionate, scalp psoriasis, water-in-oil microemulsions, biodegradable excipients, topical drug delivery, skin retention, stratum corneum, ex vivo skin permeation, pseudo-ternary phase diagram, topical corticosteroids
- MeSH terms
- Administration, Cutaneous, Animals, Biocompatible Materials, Chemistry, Pharmaceutical, Clobetasol, Emulsions, Epidermis, Excipients, Particle Size, Permeability, Psoriasis, Scalp, Skin, Skin Absorption, Swine
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