Microbial Targets for the Development of Functional Foods Accordingly with Nutritional and Immune Parameters Altered in the Elderly
Open accessAbstract
OBJECTIVE: The development of functional foods for microbiota modulation in the elderly constitutes an interesting strategy. However, for such development, specific targets, not just in terms of microbiota but also considering immune and nutritional parameters, should be identified in this population. METHODS: We analyzed the intestinal microbiota and immune parameters in 38 institutionalized elderly (mean 84 years old) and a group of 38 elderly adults (mean 62 years old). Nutritional assessments were also carried out. RESULTS: The elderly people in this study presented reduced levels of Faecalibacterium genus and Bacteroides and Blautia coccoides groups and increased Lactobacillus group, as well as reduced levels of fecal short-chain fatty acids (SCFA) when compared to younger adults. Moreover, they showed higher levels of the proinflammatory cytokines tumor necrosis factor (TNF)-α and interleukin (IL)-12 as well as the chemokine IL-8. Significant nutritional deficiencies were also observed in the elderly group. CONCLUSION: The results obtained in this study suggest potential targets for the development of functional foods for the elderly population.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The microbiota of elderly people differs from the core microbiota and diversity levels of younger adults.
“New changes appear in the senescence, the microbiota of elderly people differing from the core microbiota and diversity levels of younger adults [8,9] .”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [9]
The citation lists haven’t been fetched yet
References 45 · Cited by 80
- Authors
- Salazar, N., López, P., Valdés, L., Margolles, A., Suárez, A., Patterson, Á. M., Cuervo, A., Reyes-Gavilán, C. G. D. L., Ruas-Madiedo, P., Gonzalez, S., & Gueimonde, M.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Universidad de Oviedo (ES)
- Venue
- Journal of the American College of Nutrition
- Publisher
- Informa UK Limited
- Published
- 2013-12
- Volume
- 32
- Issue
- 6
- Pages
- 399-406
- ISSN
- 0731-5724 (ISSN-L)
- 1541-1087
- OpenAlex
- W2079981152
- Cited by
- 80
- References
- 45
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 8 · 2023: 9 · 2022: 6 · 2021: 9 · 2020: 8 · 2019: 10 · 2018: 7 · 2017: 3 · 2016: 9 · 2015: 1 · 2014: 4
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-nd
- Locations
- Journal of the American College of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Consultation of the Doctoral Thesis Database (TESEO) (Ministerio de Educación, Cultura y Deporte) (submittedVersion, cc-by-nc-nd)
- Funders
- Ministerio de Ciencia e Innovación
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- functional foods, gut microbiota, older adults, institutionalized elderly, Faecalibacterium, Bacteroides, Blautia coccoides, Lactobacillus, short-chain fatty acids, inflammatory cytokines, TNF-α, IL-12, interleukin-8, nutritional deficiency, immunological parameters, microbiota modulation
- MeSH terms
- Aged, Aged, 80 and over, Feces, Female, Humans, Intestines, Male, Middle Aged, Nutrition Assessment, Cytokines, Functional Food, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
