Factors Influencing Begomovirus Evolution and Their Increasing Global Significance: Implications for Sustainable Control

Abstract

Begomoviruses (Family Geminiviridae, Genus Begomovirus) \nhave become the most destructive group of plant viruses in tropical and subtropical regions of the world. The recent emergence of begomoviruses is notable, as these viruses have been co-evolving with their dicotyledonous plant hosts for millennia. Agricultural intensification \nhas been proposed as one of the main causes, together \nwith increases in populations of their vector Bemisia tabaci, partly due to the worldwide spread of the more fecund B-biotype. Reports of new diseases and associated epidemics are frequent. Many such reports describe the evolution of more aggressive virus variants \nthrough recombination. Little is known about the selection \npressures that seem to operate and drive begomovirus evolution towards increased virulence and an extended host range. It is apparent, however, that the genomes of begomoviruses show extreme plasticity leading to an ability to evolve very rapidly in response to changing cropping systems. Genetic diversity is created not only \nby recombination between genomic components, but also by exchange(pseudorecombination) of their genomic components, and even by acquiringDNAsequences from viruses of other genera. Recently,associations with some satellite molecules, termed DNA-β and DNA1, have also been shownto be widespread in the OldWorld. Functional DNA-β molecules encode pathogenicity determinants and are often critical for disease symptom development. They appear \nto act by suppressing host plant defense mechanism(s), such \nas post-transcriptional gene silencing (PTGS), enabling a diverse range of begomoviruses to infect particular hosts. In this review,suppression of PTGS is one of the driving forces discussed as a likely and important influence on the evolution of begomoviruses. \nThe known sources of genetic variation in begomoviruses are also considered together with the factors driving evolutionary change,the potential for limiting the extent and rate of adverse change,and therefore the potential for achieving more sustainable control of crop disease epidemics