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Associations among plasma adiponectin, hypertension, left ventricular diastolic function and left ventricular mass index
Open accessAbstract
OBJECTIVE: The purpose of this study was to characterize the relationships among plasma adiponectin, essential hypertension, left ventricular diastolic function and left ventricular hypertrophy. METHODS AND RESULTS: Plasma adiponectin concentration was assessed by radioimmunoassay, and body mass index (BMI) was measured in 275 patients (138 women and 137 men). Various echocardiographic parameters such as deceleration time (DT) and isovolumetric relaxation time (IVRT) were measured by using echocardiograms. The authors calculated left ventricular mass index (LVMI) and E/A ratio. Pulse wave velocity (PWV) was calculated by dividing the distance between the left subclavian artery ostium and the tip of the femoral sheath with the time interval between two pulse waves. The plasma adiponectin concentration of the hypertensive group was significantly lower than that of the non-hypertensive group (9.9 +/- 9.8 microg/ml vs. 12.9 +/- 9.5 microg/ml, p = 0.019). PWV in the hypertensive group was 12.0 +/- 3.9 m/s compared with 9.3 +/- 2.8 m/s in the normotensive group (p < 0.001). LVMI in the hypertensive group was 135.1 +/- 35.4 g/m2 compared with 100.5 +/- 18.7 g/m2 in the normotensive group (p < 0.001). E/A ratio (0.8 +/- 0.3 vs. 1.1 +/- 0.4, p = 0.041) was lower in the hypertensive group. DT (200.0 +/- 61.2 ms vs. 177.3 +/- 40.8 ms, p = 0.048) and IVRT (106.9 +/- 25.4 vs. 91.3 +/- 27.6 ms, p = 0.243) were higher in the hypertensive group. Plasma adiponectin showed an inverse correlation with LVMI (r = -0.525; p < 0.001) and PWV (r = -0.557; p < 0.001), IVRT (r = -0.485; p = 0.008), and showed a positive correlation with E/A ratio (r = 0.359; p < 0.001). Multiple regression analyses showed that PWV and plasma adiponectin were able to explain the 73.3% of LVMI variability (r = 0.856; p < 0.001). CONCLUSION: The results suggest that a decrease in plasma adiponectin concentration is associated with the progression of left ventricular hypertrophy with diastolic dysfunction.
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“First, an important pathophysiological contribution was suggested by the recent explosion in the number of clinical studies that have established correlations between plasma adiponectin levels and various aspects and severity of heart failure (107, 113, 143, 166, 172, 183, 198, 209, 251, 275, 282, 286, 303, 312, 366).”
From Cardiac remodeling in obesity (2008) · cites this paper as [143]
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Metadata
- Authors
- Hong, S. J., Park, C. G., Seo, H. S., Oh, D. J., & Ro, Y. M.
- Affiliations
- Korea University (KR)
- Corresponding author
- Park, Chang Gyu
- Venue
- Blood Pressure
- Publisher
- Informa UK Limited
- Published
- 2004-01
- Volume
- 13
- Issue
- 4
- Pages
- 236-242
- ISSN
- 0803-7051 (ISSN-L)
- 1651-1999
- OpenAlex
- W2016738173
- Cited by
- 121
- References
- 20
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 9 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 6 · 2013: 13 · 2012: 8
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood Pressure (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- adiponectin, essential hypertension, left ventricular diastolic function, left ventricular hypertrophy, left ventricular mass index, pulse wave velocity, arterial stiffness, diastolic relaxation, isovolumic relaxation time, deceleration time, E/A ratio, body mass index, adipokines, cardiovascular risk factors, echocardiography, pulse wave analysis
- MeSH terms
- Adult, Aged, Blood Pressure, Echocardiography, Female, Heart Ventricles, Humans, Hypertension, Male, Middle Aged, Case-Control Studies, Ventricular Function, Left, Intercellular Signaling Peptides and Proteins, Adiponectin
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