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Cited by 30Chronic Kidney Disease and DiabetesDialysis and Renal Disease ManagementAdrenal Hormones and Disorders

Corticosteroids significantly increase cystatin C levels in the plasma by promoting cystatin C production in rats

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Zhu, Xiao-Ran, Ge, Ning, Wang, Yu, Zhai, Jian-Long, Liu, Chao·2019·Renal Failure
DOI 10.1080/0886022x.2019.1638798PMC PMC6711078
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Abstract

Background: Several studies have shown that non-renal factors such as corticosteroids may increase plasma cystatin C levels without affecting kidney function. However, the mechanisms underlying this are unclear. We hypothesized that corticosteroids may increase cystatin C levels in the plasma by promoting its production in tissues. In the present study, we aimed to test our hypothesis in rats by investigating the effect of corticosteroids on cystatin C production in tissues and the glomerular filtration rate (GFR), as measured by the gold standard method (i.e., inulin clearance).Results: Dexamethasone treatment was associated with much higher concentrations of cystatin C in all organ tissue homogenates tested. Dexamethasone increased plasma cystatin C levels in rats, without any decrease in renal inulin clearance. The impact of dexamethasone on plasma and organ tissue cystatin C levels was abolished by RU486, indicating the effect was glucocorticoid receptor-mediated.Conclusions: Our study provides direct evidence that corticosteroids may increase cystatin C levels in the plasma by promoting its production, without any decrease in GFR.

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Cited by

Sorted by citations

Authors
Zhu, X.-R., Ge, N., Wang, Y., Zhai, J.-L., & Liu, C.
Affiliations
  • Department of Pharmacy, Hebei General Hospital
  • Ollscoil na Gaillimhe – University of Galway (IE)
  • Hebei Medical University (CN)
  • Cardiology Division, Hebei General Hospital
Corresponding author
Liu, Chao
ORCID
Venue
Renal Failure
Publisher
Informa UK Limited
Published
2019-01
Volume
41
Issue
1
Pages
698-703
ISSN
  • 0886-022X (ISSN-L)
  • 1525-6049
DOI
10.1080/0886022x.2019.1638798
PMC
PMC6711078
OpenAlex
W2966736528
Cited by
30
References
0
Citations by year
2026: 4 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 1 · 2020: 7 · 2017: 1
FWCI
2.70
Type
journal article
Language
en
Open access
Licence
Locations
  • Renal Failure (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Figshare (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Figshare (cc-by)
Funders
  • National Natural Science Foundation of China
  • Hebei University
  • Hebei Medical University
Topics
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
  • Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
corticosteroids, cystatin C, dexamethasone, glucocorticoid receptor, RU486, glomerular filtration rate, inulin clearance
MeSH terms
Adrenal Cortex Hormones, Animals, Dexamethasone, Glomerular Filtration Rate, Inulin, Male, Rats, Sprague-Dawley, Rats, Cystatin C

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