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Cited by 66Temporomandibular Joint DisordersSleep and related disordersOrthodontics and Dentofacial Orthopedics

The DOI matches its Crossref record.

The Effect of Four-Week Administration of Amitriptyline on Sleep Bruxism. A Double-Blind Crossover Clinical Study

Raigrodski, Ariel J., Christensen, Larry V., Mohamed, Shawky E., Gardiner, Diana M.·2001·CRANIO®
DOI 10.1080/08869634.2001.11746147
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Abstract

The purpose of this study was to evaluate the effect of a tricyclic antidepressant (amitriptyline) on nocturnal masseteric activity and duration of sleep in bruxists. Using a randomized, double blind, crossover design, ten females (mean age 39 yrs, +/- sd seven yrs) received active (amitriptyline 25 mg/night) and inactive (placebo 25 mg/night) medication, over a period of four weeks each. A portable EMG integrator recorded the nocturnal, unilateral, and cumulative myoelectrical activity (microV/min of sleep) of the masseter muscle during the fourth and eighth weeks of the study. The results showed that amitriptyline did not significantly decrease the mean EMG activity (df = 9, alpha = 0.05, paired-t = 0.892, p = 0.3964), nor did it significantly increase the duration of sleep (df = 9, alpha = 0.05, paired-t = 2.140, p = 0.061). The results of this study do not support the administration of 25 mg of amitriptyline per night over a period of four weeks for the management of sleep bruxism.

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Crossref · 10.1080/08869634.2001.11746147

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  • Another study found no improvement in total sleep time for amitriptyline.

    “and another found no improvement in total sleep time for amitriptyline (Raigrodski et al., 2001).”

    From Antidepressants and their effect on sleep (2005) · cites this paper as Raigrodski et al., 2001

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Research works printed but not linked: 12

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  2. Haddox JD: Coanalgesic agents. In: Raj PP, Pain medicine, a comprehensive review. St. Louis: Mosby, 1996; 142–144.
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  5. 10.1016/0304-3959(87)90036-4 · DOI
  6. 10.1111/j.1365-2044.1992.tb02383.x · DOI
  7. 10.1212/WNL.37.4.589 · DOI
  8. 10.1016/0304-3959(85)90009-0 · DOI
  9. 10.1001/archneur.1979.00500470065013 · DOI
  10. Mohamed SE, Christensen LV, Penchas J: A randomized double-blind clinical trial of the effect of amitriptyline on nocturnal masseteric motor activity (sleep bruxism). J Craniomandib Pract 1997; 15: 326–332.
  11. 10.1109/TBME.1983.325169 · DOI
  12. 10.1177/00220345990780080901 · DOI

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Metadata

Authors
Raigrodski, A. J., Christensen, L. V., Mohamed, S. E., & Gardiner, D. M.
Affiliations
Louisiana State University (US)
Venue
CRANIO®
Publisher
Informa UK Limited
Published
2001-01
Volume
19
Issue
1
Pages
21-25
ISSN
  • 0734-5410 (ISSN-L)
  • 0886-9634
  • 2151-0903
DOI
10.1080/08869634.2001.11746147
OpenAlex
W157768469
Cited by
66
References
0
Citations by year
2026: 5 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 5 · 2014: 2 · 2013: 2 · 2012: 2
FWCI
2.46
Type
journal article
Language
en
Open access
closed
Locations
  • CRANIO® (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Dentistry › Oral Surgery › Temporomandibular Joint Disorders
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Health Sciences › Dentistry › Orthodontics › Orthodontics and Dentofacial Orthopedics
Keywords
amitriptyline, sleep bruxism, tricyclic antidepressants, masseter muscle activity, muscle electrical activity, sleep duration, bruxism treatment, placebo comparison
MeSH terms
Adult, Amitriptyline, Analysis of Variance, Antidepressive Agents, Tricyclic, Double-Blind Method, Electromyography, Female, Follow-Up Studies, Humans, Masseter Muscle, Placebos, Sleep, Statistics as Topic, Normal Distribution, Linear Models, Treatment Outcome, Cross-Over Studies, Sleep Bruxism

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