Disruption and eradication of P. aeruginosa biofilms using nitric oxide-releasing chitosan oligosaccharides
Open accessAbstract
Biofilm disruption and eradication were investigated as a function of nitric oxide- (NO) releasing chitosan oligosaccharide dose and the results compared with control (i.e., non-NO-releasing) chitosan oligosaccharides and tobramycin. Quantification of biofilm expansion/contraction and multiple-particle tracking microrheology were used to assess the structural integrity of the biofilm before and after antibacterial treatment. While tobramycin had no effect on the physical properties of the biofilm, NO-releasing chitosan oligosaccharides exhibited dose-dependent behavior with biofilm degradation. Control chitosan oligosaccharides increased biofilm elasticity, indicating that the scaffold may mitigate the biofilm disrupting power of nitric oxide somewhat. The results from this study indicate that nitric oxide-releasing chitosan oligosaccharides act as dual-action therapeutics capable of eradicating and physically disrupting P. aeruginosa biofilms.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Biodegradable polymers such as citrate-based or saccharide-based polymers (dextran, chitosan) are attractive scaffolds for NO delivery because of natural occurrence, biodegradability, tolerability to mammalian cells, and accessibility for NO donor functionalization.
“Lastly, several biodegradable polymers, such as citrate-based225 or saccharide-based polymers (e.g., dextran227,244 and chitosan86,87,220) provide very attractive scaffolds for NO delivery because of their natural occurrence, biodegradability, tolerability to mammalian cells and accessibility for NO donor functionalization reactions.220,244,245”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [87]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 64 · Cited by 53
- Authors
- Reighard, K. P., Hill, D. B., Dixon, G. A., Worley, B. V., & Schoenfisch, M. H.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Schoenfisch, Mark H.
- Venue
- Biofouling
- Publisher
- Informa UK Limited
- Published
- 2015-11-26
- Volume
- 31
- Issue
- 9-10
- Pages
- 775-787
- ISSN
- 0892-7014 (ISSN-L)
- 1029-2454
- PMC
- PMC4695972
- OpenAlex
- W2188835062
- Cited by
- 53
- References
- 64
- Citations by year
- 2025: 3 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 7 · 2019: 7 · 2018: 6 · 2017: 6 · 2016: 2
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biofouling (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- Directorate for Biological Sciences (DMS1100281)
- National Institutes of Health (AI112029)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Physical Sciences › Materials Science › Biomaterials › Nanocomposite Films for Food Packaging
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Keywords
- Pseudomonas aeruginosa, biofilm eradication, nitric oxide, chitooligosaccharides, tobramycin, microrheology
- MeSH terms
- Anti-Bacterial Agents, Nitric Oxide, Oligosaccharides, Pseudomonas aeruginosa, Rheology, Tobramycin, Biofilms, Chitosan
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
