Effects of Asiaticoside Treatment on the Survival of Random Skin Flaps in Rats
Abstract
Background: Asiaticoside (AS) is extracted from the traditional herbal medicine Centella asiatica, and has angiogenic, antioxidant, anti-inflammatory, and wound-healing effects. We investigated the effects of AS on skin flap survival. Methods: Dorsal McFarlane flaps were harvested from 36 rats and divided into two groups: an experimental group treated with 40 mg/kg AS administered orally once daily, and a control group administered normal saline in an identical manner. On day 2, superoxide dismutase (SOD) and malondialdehyde (MDA) levels, and production of the cytokines tumor necrosis factor-α and interleukin (IL)-6 were evaluated. On day 7, tissue slices were stained with hematoxylin and eosin. The expression of vascular endothelial growth factor (VEGF), IL-6, and IL-1β were immunohistochemically evaluated. Microcirculatory flow was measured using laser Doppler flowmetry. Flap angiography, using the lead oxide-gelatin injection technique, was performed with the aid of a soft X-ray machine. Results: The AS group exhibited greater mean flap survival area, improved microcirculatory flow, and higher expression levels of SOD and VEGF compared with the control group. However, MDA levels and the inflammatory response were significantly reduced. Conclusions: AS exhibits promise as a therapeutic option due to its effects on the viability and function of random skin flaps in rats.
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Enhancement of wound healing, particularly angiogenesis, might be due to stimulation of collagen I and increased production of FGF and VEGF, via activation of the TβR2 kinase-independent pathway.
“The enhancement of wound healing, particularly angiogenesis [30,31] might be due to the stimulation of collagen I, as well as the increased production of Fibroblast Growth Factor (FGF) and Vascular Endothelial Growth Factor (VEGF). This occurs via the activation of the TβR2 kinase-independent pathway [32,33].”
From A systematic review of the effect of Centella asiatica on wound healing (2022) · cites this paper as [33]
C. asiatica has an anti-inflammatory effect observed by reduction in IL-1β, IL-6, TNFα, PGE2, and COX-2.
“C. asiatica has shown an anti-inflammatory effect observed by the reduction in Interleukin-1β (IL-1β), Interleukin-6 (IL-6) and Tumour Necrosis Factor α (TNFα) [33,36,37], as well as prostaglandin E2 (PGE2) [36,38], and cyclooxygenase-2 (COX-2) [39].”
From A systematic review of the effect of Centella asiatica on wound healing (2022) · cites this paper as [33]
This enhancement might result from the anti-inflammatory effect of C. asiatica due to reduction in IL-1β, IL-6, TNFα, PGE2, and COX-2.
“This might result from the anti-inflammatory effect caused by C. asiatica due to the reduction in IL-1β, IL-6 and TNFα [33,36,37], as well as prostaglandin E2 (PGE2) [36,38] and cyclooxygenase-2 (COX-2) [39].”
From A systematic review of the effect of Centella asiatica on wound healing (2022) · cites this paper as [33]
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References 34 · Cited by 23
- Authors
- Feng, X., Huang, D., Lin, D., Zhu, L., Zhang, M., Chen, Y., & Wu, F.
- Affiliations
- Department of Orthopedics, People's Hospital of YingDe City Guangdong Province
- Guangdong Provincial People's Hospital (CN)
- Wenzhou Medical University (CN)
- Corresponding author
- Feng, Xiguang
- Venue
- Journal of Investigative Surgery
- Publisher
- Informa UK Limited
- Published
- 2019-03-21
- Volume
- 34
- Issue
- 1
- Pages
- 107-117
- ISSN
- 0894-1939 (ISSN-L)
- 1521-0553
- OpenAlex
- W2923001015
- Cited by
- 23
- References
- 34
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 2
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Investigative Surgery (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Natural Science Foundation of Zhejiang Province (Y16H060039)
- Topics
- Health Sciences › Medicine › Surgery › Reconstructive Surgery and Microvascular Techniques
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- asiaticoside, Centella asiatica, random skin flap, flap survival, angiogenesis, microcirculation, oxidative stress, superoxide dismutase, malondialdehyde, vascular endothelial growth factor, TNF-α, interleukin-6, IL-1β, wound healing, anti-inflammatory activity
- MeSH terms
- Animals, Graft Survival, Microcirculation, Skin, Surgical Flaps, Triterpenes, Rats, Sprague-Dawley, Neovascularization, Physiologic, Vascular Endothelial Growth Factor A, Rats
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