The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
PATHOGENICITY OF A SPECIAL-PURPOSE GLASS MICROFIBER (E GLASS) RELATIVE TO ANOTHER GLASS MICROFIBER AND AMOSITE ASBESTOS
Abstract
This article describes the activity of an E-glass microfiber (104E) during chronic inhalation and intraperitoneal injection studies in rats. Results are compared with another microfiber of similar dissolution rate (k(dis)), code 100/475, and the more durable amosite asbestos, both of which we had previously used in similar experiments (Davis et al., 1996). Rats were exposed to aerosol concentrations of 1000 fibers (longer than 5 microm)/ml, as measured by optical microscopy, for 7 h/day, 5 days/wk. Subgroups of rats were followed for mean lung burden, early and late signs of fibrosis, and tumor incidence. At the end of 12 mo of exposure, the mean number of 104E fibers of all lengths in the lungs was approximately double that for amosite but two-thirds of that for 100/475. For fibers longer than 15 microm, the mean 104E burden was similar to that for the amosite and more than twice that of the 100/475. After a 12-mo recovery period, the retained lung burdens (of fibers of all lengths) were approximately 30% of those at 12 mo for both microfibers, and somewhat higher (approximately 44%) for amosite. Amosite and 100/475 fibers longer than 15 microm were more persistent in the lungs than 104E fibers. The chemical composition of 104E fibers did not appear to have been significantly altered by up to 24 mo of residence in lung tissue, whereas the composition of 100/475 was substantially altered over the same time period. From the inhalation study, out of the pathology subgroup of 43…
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“According to Davis et al. [105] and Cullen et al. [106] the clearance rate of both fibers < 5 μm and > 20 μm was quite similar (≈60%), while that of fibers > 5 μm was lower (≈44%).”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [106]
In the citing paper
“With amphiboles, two studies reported lower clearance of long fibers in comparison with short fibers.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [106]
Citations
Cites
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PERSISTENCE OF MAN-MADE MINERAL FIBRES (MMMF) AND ASBESTOS IN RAT LUNGS
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Cited by
Boulanger, G., Andujar, P., Pairon, J.-C., Billon-Galland, M.-A., Dion, C., Dumortier, P., Brochard, P., Sobaszek, A., Bartsch, P., Paris, C., et al. (2014) · Environmental Health · doi:10.1186/1476-069x-13-59 · Cited by 176
Synthetic vitreous fibers: A review toxicology, epidemiology and regulations
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Metadata
- Authors
- R. T.Cullen, A. S.
- Venue
- Inhalation Toxicology
- Publisher
- Informa UK Limited
- Published
- 2000-01
- Volume
- 12
- Issue
- 10
- Pages
- 959-977
- ISSN
- 0895-8378
- 1091-7691
- Cited by
- 16
- References
- 24
- Language
- en
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