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Cited by 133Air Quality and Health ImpactsAtmospheric chemistry and aerosolsAntioxidant Activity and Oxidative Stress

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Determination of metal-based hydroxyl radical generating capacity of ambient and diesel exhaust particles

DiStefano, Emma, Eiguren-Fernandez, Arantzazu, Delfino, Ralph J., Sioutas, Constantinos, Froines, John R., Cho, Arthur K.·2009·Inhalation Toxicology
DOI 10.1080/08958370802491433
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Abstract

Numerous studies have suggested the association of reactive oxygen species (ROS) with adverse health effects derived from exposure to airborne particulate matter (PM) and diesel exhaust particles (DEP). This redox activity has been attributed to both inorganic and organic species present in these particles, but a clear distinction has not been established between the contribution of each. This article describes an application of an analytical procedure, based on the reaction of salicylic acid with hydroxyl radical to form dihydroxybenzoate (DHBA) isomers, to measure transition metal-based redox activity associated with ambient and diesel exhaust particles. In the procedure, ascorbic acid (AA) is used as electron source for reduction of metal ions and oxygen to generate superoxide, which is further reduced to hydroxyl radical in the presence of transition metal ions. Hydroxyl radical reacts with salicylate to generate DHBA isomers, which are measured by high-performance liquid chromatography (HPLC) with electrochemical detector. Both copper (Cu) and iron (Fe) ions generated DHBA isomers in a concentration-dependent manner but at different rates. The procedure was applied to DEP and ambient particles and the results showed Cu ion to be the major contributor to DHBA formation. The procedure provides a quantitative measure of transition metal-based redox activity associated with ambient samples with different physicochemical properties.

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  • Transition metals within PM can generate hydroxyl radicals by Fenton reactions.

    “Second, transition metals within PM can generate highly reactive hydroxyl radicals (•OH) by Fenton reactions17.”

    From Air Pollution and Skin Diseases (2025) · cites this paper as [17]

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Metadata

Authors
DiStefano, E., Eiguren-Fernandez, A., Delfino, R. J., Sioutas, C., Froines, J. R., & Cho, A. K.
Affiliations
University of California, Los Angeles (US)
Corresponding author
DiStefano, Emma
ORCID
Venue
Inhalation Toxicology
Publisher
Informa UK Limited
Published
2009-07-31
Volume
21
Issue
9
Pages
731-738
ISSN
  • 0895-8378 (ISSN-L)
  • 1091-7691
DOI
10.1080/08958370802491433
OpenAlex
W2125497202
Cited by
133
References
0
Citations by year
2026: 2 · 2025: 8 · 2024: 6 · 2023: 6 · 2022: 7 · 2021: 5 · 2020: 9 · 2019: 8 · 2018: 10 · 2017: 8 · 2016: 8 · 2015: 15 · 2014: 5 · 2013: 8 · 2012: 10
FWCI
6.63
Type
journal article
Language
en
Open access
closed
Locations
  • Inhalation Toxicology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Environmental Health Sciences (5P30-ES07048, P30ES007048)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
  • Physical Sciences › Earth and Planetary Sciences › Atmospheric Science › Atmospheric chemistry and aerosols
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords
hydroxyl radicals, diesel exhaust particles, ambient particulate matter, copper, iron, salicylic acid, superoxide, reactive oxygen species, vitamin C
MeSH terms
Air Pollutants, Vehicle Emissions, Chromatography, High Pressure Liquid, Copper, Ions, Iron, Isomerism, Oxidation-Reduction, Particle Size, Hydroxyl Radical, Salicylic Acid, Particulate Matter, Hydroxybenzoates

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