Growth Differentiation Factor 15 and Its Role in Carcinogenesis: An Update
Abstract
Growth differentiation factor-15 (GDF-15) is a novel cytokine secreted by a variety of cells like macrophages, adipocytes, normally expressed in high amounts by placenta. It is also highly expressed in multiple carcinomas like Colon, Breast, Pancreas, Liver, and Ovarian. Several reports on serum GDF-15 as a potential biomarker for diagnosis and prognosis of cancer are hampered by the lack of robust data, with large sample size and critical patient recruitment. However, experimental accounts on cancer tumors, cell lines, and animal models suggest GDF-15's role in cancer progression via endothelial mesenchymal transition, angiogenesis, metastasis, drug resistance and even stemness of various cancers. GDF-15 could be the point of amalgamation for the various hallmarks of cancer and can prove a useful therapeutic target in cancer. The current review was conceptualized with a thought of critically appraising the existing information of GDF-15 in carcinogenesis.
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Elevated levels of GDF15 have been linked to tumor growth and poor prognosis in cancer patients.
“Elevated levels of GDF15 have been linked to tumor growth and poor prognosis in cancer patients raising the question as to whether GDF15 serves as a tumor suppressor or promoter and a target for the treatment of cancer (84, 85, 99).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [84]
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References 88 · Cited by 41
- Authors
- Modi, A., Dwivedi, S., Roy, D., Khokhar, M., Purohit, P., Vishnoi, J., Pareek, P., Sharma, S., Sharma, P., & Misra, S.
- Affiliations
- All India Institute of Medical Sciences Jodhpur (IN)
- Department of Biochemistry, AIIMS Jodhpur, Jodhpur, Rajasthan, India;
- Department of Oncosurgery, AIIMS Jodhpur, Jodhpur, Rajasthan, India;
- Corresponding author
- Purohit, Purvi
- ORCID
- Venue
- Growth Factors
- Publisher
- Informa UK Limited
- Published
- 2019-07-04
- Volume
- 37
- Issue
- 3-4
- Pages
- 190-207
- ISSN
- 0897-7194 (ISSN-L)
- 1029-2292
- OpenAlex
- W2986803823
- Cited by
- 41
- References
- 88
- Citations by year
- 2025: 4 · 2024: 9 · 2023: 8 · 2022: 6 · 2021: 8 · 2020: 6
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Growth Factors (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › GDF15 and Related Biomarkers
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- growth differentiation factor 15, GDF15, carcinogenesis, tumor markers, cancer diagnosis and prognosis, endothelial-to-mesenchymal transition, angiogenesis, metastasis, drug resistance, cancer stemness, cancer hallmarks, therapeutic target, colon cancer, breast cancer, pancreatic cancer, liver cancer, ovarian cancer
- MeSH terms
- Humans, Neoplasm Metastasis, Neoplasms, Neovascularization, Pathologic, Prognosis, Biomarkers, Tumor, Drug Resistance, Neoplasm, Cell Proliferation, Growth Differentiation Factor 15, Carcinogenesis
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