Human herpesvirus 6 meningitis in an adult
Open accessAbstract
Many cases of viral meningitis are idiopathic, but increased utilization of polymerase chain reaction testing has enabled physicians to better recognize rare causes of viral meningitis. This will likely continue to improve the rate of causative agent identification in seemingly idiopathic viral meningitis, including this case of human herpesvirus 6 (HHV-6) meningitis in an immunocompetent adult patient. More common viral etiologies need to be excluded before diagnosing HHV-6 meningitis, as this maximizes pretest probability and therefore increases validity of a positive result. By efficiently diagnosing HHV-6 meningitis, proper treatment protocols can be initiated earlier to reduce morbidity and mortality. Given the rarity of HHV-6 meningitis in immunocompetent adults, there are no established standard treatment guidelines; previous reported cases, as well as this case, suggest that either intravenous ganciclovir or intravenous foscarnet are the most reasonable first-line treatment options.
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There is no specific, validated treatment for HHV-6 meningoencephalitis in immunocompetent adults, given the rarity of this condition.
“We lack a specific, validated treatment for HHV-6 meningoencephalitis in immunocompetent adults, given the rarity of this condition [7], [10], [15].”
From Meningoencephalitis in a background of inherited chromosomic integration of HHV-6 and CMV infection in an immunocompetent adult, which one is the culprit? (2025) · cites this paper as [10]
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References 5 · Cited by 6
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- Authors
- Maniam, G. B., Wilkerson, H., & Milton, J. S.
- Affiliations
- Texas Tech University Health Sciences Center (US)
- Corresponding author
- Maniam, Ganesh B.
- ORCID
- Maniam, Ganesh B.
- Venue
- Baylor University Medical Center Proceedings
- Publisher
- Informa UK Limited
- Published
- 2020-01-27
- Volume
- 33
- Issue
- 2
- Pages
- 246-247
- ISSN
- 0899-8280 (ISSN-L)
- 1525-3252
- PMC
- PMC7155960
- OpenAlex
- W3004200973
- Cited by
- 6
- References
- 5
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 2
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Baylor University Medical Center Proceedings (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Keywords
- human herpesvirus 6, viral meningitis, immunocompetent adult, polymerase chain reaction diagnosis, ganciclovir, foscarnet, antiviral therapy
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