Delphinidin Prevents Disuse Muscle Atrophy and Reduces Stress-Related Gene Expression
Abstract
Delphinidin is a member of the anthocyanidin class of plant pigments. We examined the effects of delphinidin on muscle atrophy. Oral administration of delphinidin suppressed the muscle weight loss induced by mechanical unloading. Microarray analysis showed that delphinidin suppresses the upregulation of oxidative stress-related gene expression, including the expression of Cbl-b. Thus, delphinidin may prevent unloading-mediated muscle atrophy.
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Oral administration of delphinidin prevents disuse muscle atrophy by inducing miR-23a expression and nuclear factor of activated T cells 3 and suppressing MuRF1 expression in skeletal muscle of C57BL/6J mice.
“For instance, oral administration of delphinidin prevents disuse muscle atrophy by inducing the miR-23a expression and nuclear factor of activated T cells 3 and suppressing MuRF1 expression in skeletal muscle of C57BL/6J mice [117,118].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [117]
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References 27 · Cited by 19
- Authors
- Murata, M., Kosaka, R., Kurihara, K., Yamashita, S., & Tachibana, H.
- Affiliations
- Kyushu University (JP)
- Corresponding author
- Tachibana, Hirofumi
- ORCID
- Tachibana, Hirofumi
- Venue
- Bioscience Biotechnology and Biochemistry
- Publisher
- Informa UK Limited
- Published
- 2016-08-02
- Volume
- 80
- Issue
- 8
- Pages
- 1636-1640
- ISSN
- 0916-8451 (ISSN-L)
- 1347-6947
- OpenAlex
- W2397919420
- Cited by
- 19
- References
- 27
- Citations by year
- 2026: 2 · 2023: 2 · 2022: 6 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 1
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Bioscience Biotechnology and Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (15H02448, 22228002)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Keywords
- delphinidin, anthocyanidins, muscle atrophy, disuse atrophy, mechanical unloading, oxidative stress, gene expression, Cbl-b, stress-related genes, oral administration
- MeSH terms
- Superoxide Dismutase-1, NADPH Oxidase 4, Animals, Anthocyanins, Body Weight, Catalase, Cell Line, Gene Expression Regulation, Male, Mice, Inbred C57BL, Muscular Atrophy, Neuropeptides, Signal Transduction, Oxidative Stress, Muscle, Skeletal, NADPH Oxidases, Hindlimb Suspension, rac1 GTP-Binding Protein, Gene Expression Profiling, Myoblasts, Adaptor Proteins, Signal Transducing, Proto-Oncogene Proteins c-cbl, Mice
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