Propionibacterium acnes related anti-inflammation and skin hydration activities of madecassoside, a pentacyclic triterpene saponin from Centella asiatica
Abstract
Madecassoside is a major pentacyclic triterpene saponin from Centella asiatica with multiple pharmaceutical activities. In this study, we focused on its Propionibacterium acnes related anti-inflammation and skin hydration activities, both of which play important roles in skin homeostasis and barrier function. Madecassoside significantly inhibited the pro-inflammatory cytokine IL-1β, TLR2 and nuclear translocation of NF-κB in P. acnes stimulated THP-1 human monocytic cells. In addition, madecasssoside exhibited significant effects on enhancement of skin hydration through increasing the key moisturizing contributors of aquaporin-3, loricrin and involucrin in HaCaT keratinocytes as well as hyaluronan (HA) secretion in human dermal fibroblasts. The upregulation of HA synthases (HAS1, HAS2, HAS3) and inhibition to ROS formation accounted for the increment of HA content. Together, the in vitro study implied the potential medical and cosmetic application of madecassoside in skin protection.
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Shen et al. showed that madecassoside, a major triterpenoid of C. asiatica, upregulated HAS1-3 and AQP3 in human keratinocytes, increasing hyaluronan content and supporting moisture retention.
“Shen et al. [28], showed that madecassoside, a major triterpenoid of C. asiatica, upregulated HAS1–3 and AQP3 in human keratinocytes, increasing hyaluronan content and supporting moisture retention.”
Asiaticoside and madecassoside have collagen-stimulating, hydrating, scar and burn-healing properties.
“Furthermore, these compounds have collagen‐stimulating, hydrating, scar and burn‐healing properties, 35 , 36”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [36]
Madecassoside notably enhances skin hydration and moisturization both in vitro and in vivo.
“Moreover, madecassoside can notably enhance skin hydration and moisturization both in vitro and in vivo, proving to be both medically and cosmetically beneficial.”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [36]
Madecassoside significantly protects skin against acne inflammation by inhibiting production of pro-inflammatory cytokines IL-1β and TLR2 released by P. acnes in P. acnes-stimulated THP-1 human monocytic cells.
“Madecassoside is confirmed to significantly protect the skin against acne inflammation by inhibiting the production of pro‐inflammatory cytokines, IL‐1β and TLR2, released by P. acnes in P. acnes‐stimulated THP‐1 human monocytic cells.”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [36]
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References 35 · Cited by 54
- Authors
- Shen, X., Guo, M., Yu, H., Liu, D., Lu, Z., & Lu, Y.
- Affiliations
- East China University of Science and Technology (CN)
- Technology Center, Shanghai Inoherb Co. Ltd, Shanghai, People’s Republic of China
- State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, People’s Republic of China
- Corresponding author
- Lu, Zhi
- Venue
- Bioscience Biotechnology and Biochemistry
- Publisher
- Informa UK Limited
- Published
- 2019-03-04
- Volume
- 83
- Issue
- 3
- Pages
- 561-568
- ISSN
- 0916-8451 (ISSN-L)
- 1347-6947
- OpenAlex
- W2901504929
- Cited by
- 54
- References
- 35
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 6 · 2023: 10 · 2022: 6 · 2021: 10 · 2020: 7 · 2019: 1
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Bioscience Biotechnology and Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Industry-University-Institute collaboration of Baoshan District Committee of Science and Technology (17-C-1)
- Fundamental Research Funds for the Central Universities (22221818014)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- madecassoside, Centella asiatica, Propionibacterium acnes, anti-inflammatory activity, skin hydration, IL-1β, TLR2, NF-κB nuclear translocation, THP-1 cells, AQP3, loricrin, involucrin, hyaluronic acid, hyaluronan synthase, reactive oxygen species, skin barrier function, cosmetic applications
- MeSH terms
- Anti-Inflammatory Agents, Cell Line, Cell Survival, Humans, Hyaluronic Acid, Propionibacterium acnes, Skin, Triterpenes, Signal Transduction, NF-kappa B, Centella, Toll-Like Receptor 2, Interleukin-1beta
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