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Enhancement of the mechanical properties of chitosan
Abstract
Chitosan (CS) has been investigated for copious applications in the biomedical, industrial and environmental fields owing to its diverse advantageous traits. Nevertheless, CS exhibits debilitated mechanical stability. This debilitated mechanical stability constitutes an obstacle to nearly all of CS's applications. Hence, in this review we discussed different approaches that could be adopted in order to escalate the mechanical properties of CS. Chemical cross-linking was among these approaches where CS was chemically cross-linked with various agents, such as glutaraldehyde, vanillin, and genipin. Different plasticizers were also incorporated with CS. Moreover, nano-materials were added to CS so as to form nano-composites of enhanced mechanical properties. Porogens were also employed to increase the surface area available for the CS's physical and chemical cross-linking processes. Other reports attempted to modify the fabrication conditions and gelling system of CS as a means of producing mechanically stable CS gels.
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“Although CS has numerous valuable advantages, it also has several limitations that affect its use in the delivery of anticancer drugs. These include low thermal stability [11,12] and ductility [13,14], poor solubility of CS above pH 6.5 [15,16], high hydrophilicity and swelling properties, which may lead to premature drug release and reduced structural stability.”
From Chitosan-Based Drug Delivery Systems for Targeted Chemotherapy in Colorectal Cancer: A Scoping Review (2025) · cites this paper as [14]
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Cited by
Sorted by citations
Piotrowska, U., Szatko, J., Nowakowska, A., Klimaszewska, E., Ogorzałek, M., & Sobczak, M. (2025) · Marine Drugs · doi:10.3390/md23120467 · Cited by 14
Metadata
- Authors
- Wahba, M. I.
- Affiliations
- Department of Chemistry of Natural and Microbial Products, National Research Centre, Giza, Egypt;
- ORCID
- Wahba, Marwa I.
- Venue
- Journal of Biomaterials Science, Polymer Edition
- Publisher
- Informa UK Limited
- Published
- 2019-11-25
- Volume
- 31
- Issue
- 3
- Pages
- 350-375
- ISSN
- 0920-5063
- 1568-5624
- Cited by
- 126
- References
- 0
- Language
- en
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