Genetic-based signatures of the latitudinal differences in chronotype
Abstract
The natural cycles of night and day, and their length, remain stable in near-equatorial African regions but they vary with latitude and season in Eurasia. This new environmental factor might shape the adaptation of circadian rhythms of Eurasians after the out-of-African dispersal of their African ancestors. To identify the genetic-based signatures of this adaptation, geographic variation in allele frequencies of more than 2300 genetic variants was analyzed using data from 5 African and 11 Eurasian populations of the 1000 Genomes Project. The genetic signatures of latitude-dependent polygenic selection were found more frequently within non-coding DNA regions associated with morningness–eveningness in genome-wide association studies (GWASs) than among polymorphisms hinted by GWASs of other traits/diseases and among polymorphisms sampled from pseudogenes and from protein-coding regions in either circadian clock genes or reference genes. Some of such variants were located within the introgressions of the Neanderthal’s genome into the genomes of Eurasians.
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Previous studies have identified two introgressed loci associated with sleep patterns.
“previous studies have identified two introgressed loci associated with sleep patterns (Dannemann and Kelso 2017; Putilov et al. 2019).”
From Archaic Introgression Shaped Human Circadian Traits (2023) · cites this paper as Putilov et al. 2019
An introgressed haplotype on chr2 is associated with chronotype and increases in frequency with latitude.
“Motivated by the previous discovery of an introgressed haplotype on chr2 that is associated with chronotype and increases in frequency with latitude (Dannemann and Kelso 2017; Putilov et al. 2019), we also tested each introgressed circadian variant for a correlation between allele frequency and latitude in modern non-African populations from the 1000 Genomes Project.”
From Archaic Introgression Shaped Human Circadian Traits (2023) · cites this paper as Putilov et al. 2019
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References 52 · Cited by 4
- Authors
- Putilov, A. A., Dorokhov, V. B., Puchkova, A. N., Arsenyev, G. N., & Sveshnikov, D. S.
- Affiliations
- Institute of Molecular Biology and Biophysics (RU)
- Laboratory of Sleep/Wake Neurobiology, the Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences, Moscow, Russia
- Russian Academy of Sciences (RU)
- Peoples' Friendship University of Russia (RU)
- Corresponding author
- Putilov, Arcady A.
- Venue
- Biological Rhythm Research
- Publisher
- Informa UK Limited
- Published
- 2018-04-23
- Volume
- 50
- Issue
- 2
- Pages
- 255-271
- ISSN
- 0929-1016 (ISSN-L)
- 1744-4179
- OpenAlex
- W2799327307
- Cited by
- 4
- References
- 52
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2021: 1
- FWCI
- 0.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Rhythm Research (publishedVersion)
- Funders
- Russian Foundation for Basic Research (grant number 16-06-00235-a, grant numbers 15-06-10909/17- OGON], 16-06-01054/17-OGON, 16-06-00235-a, 15-06-10909/17-OGON)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Keywords
- chronotype, latitude, polygenic selection, allele frequency variation, non-coding variants, clock genes, Neanderthal introgression, 1000 Genomes Project
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