Assessment of cognitive domains during treatment with OROS methylphenidate in adolescents with ADHD
Abstract
AIM: To psychometrically assess cognitive domains in adolescents with ADHD during long-term open treatment with robust dosing of extended-release methylphenidate (OROS MPH). METHODS: Data were derived from a prospective clinical study of adolescent ADHD, employing the Cambridge Neuropsychological Test Automated Battery (CANTAB), before and after up to one year of treatment with OROS MPH. In the absence of placebo control, a similar age and gender group of youth without ADHD served as comparators. RESULTS: During the course of treatment with OROS MPH, ADHD youth's performance significantly improved across multiple CANTAB tasks, including spatial working memory, rapid visual processing, verbal recognition memory, set shifting, and inhibition/vigilance. ADHD subjects' scores in several CANTAB tasks, including spatial working memory, planning, and set shifting, were significantly more impaired at baseline compared to the non-ADHD comparison group; these significant differences were no longer seen at endpoint. CONCLUSIONS: Statistically significant improvements in multiple cognitive domains were observed in a sample of adolescents with ADHD over the course of 12 months of robust treatment with extended-release methylphenidate. Rigorous, monitored stimulant treatment may be associated with objectively determined cognitive benefits; however, practice effects in this open trial cannot be ruled out. Further study on this important topic is warranted.
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Deficits observed on the CANTAB among individuals with ADHD improve in the context of stimulant treatment.
“Similarly, deficits observed on the CANTAB among individuals with ADHD improve in the context of stimulant treatment, suggesting these are key targets for other novel interventions for this disorder [38].”
From Proof-of-concept study of an at-home, engaging, digital intervention for pediatric ADHD (2018) · cites this paper as [38]
Medication management has a very significant effect on core symptoms of ADHD but only equivocal effects on specific executive functions.
“medication management, the mostly commonly utilized treatment for ADHD, has a very significant effect on core symptoms of ADHD but only equivocal effects on specific executive functions [38–40].”
From Proof-of-concept study of an at-home, engaging, digital intervention for pediatric ADHD (2018) · cites this paper as [38]
Medication management is the most commonly utilized treatment for ADHD.
“medication management, the mostly commonly utilized treatment for ADHD, has a very significant effect on core symptoms of ADHD but only equivocal effects on specific executive functions [38–40].”
From Proof-of-concept study of an at-home, engaging, digital intervention for pediatric ADHD (2018) · cites this paper as [38]
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References 36 · Cited by 14
- Authors
- Hammerness, P., Fried, R., Petty, C., Meller, B., & Biederman, J.
- Affiliations
- Harvard University (US)
- Corresponding author
- Hammerness, Paul
- Venue
- Child Neuropsychology
- Publisher
- Informa UK Limited
- Published
- 2013-05-02
- Volume
- 20
- Issue
- 3
- Pages
- 319-327
- ISSN
- 0929-7049 (ISSN-L)
- 1744-4136
- OpenAlex
- W2030245427
- Cited by
- 14
- References
- 36
- Citations by year
- 2026: 2 · 2025: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2014: 3
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Child Neuropsychology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- attention deficit hyperactivity disorder, extended-release methylphenidate, OROS methylphenidate, stimulant medication, cognitive function, adolescents, spatial working memory, rapid visual processing, recognition memory, set-shifting, inhibition, sustained attention, planning, CANTAB
- MeSH terms
- Adolescent, Central Nervous System Stimulants, Attention, Attention Deficit Disorder with Hyperactivity, Cognition, Delayed-Action Preparations, Dose-Response Relationship, Drug, Female, Humans, Male, Memory, Short-Term, Methylphenidate, Neuropsychological Tests, Prospective Studies, Psychometrics, Psychomotor Performance, Reproducibility of Results, Treatment Outcome
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