Involvement of fractalkine and macrophage inflammatory protein‐1 alpha in moderate‐severe depression
Open accessAbstract
MODERATE‐severe depression (MSD) is linked to overexpression of proinflammatory cytokines and chemokines. Fractalkine (FKN) and macrophage inflammatory protein‐1 alpha (MIP‐1α) are, respectively, members of CX3C and C‐C chemokines, and both are involved in recruiting and activating mononuclear phagocytes in the central nervous system. We analysed the presence of FKN and MIP‐1α in sera of untreated MSD patients and healthy donors. High FKN levels were observed in all MSD patients as compared with values only detectable in 26% of healthy donors. MIP‐1α was measurable in 20% of patients, while no healthy donors showed detectable chemokine levels. In conclusion, we describe a previously unknown involvement of FKN in the pathogenesis of MSD, suggesting that FKN may represent a target for a specific immune therapy of this disease.
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CX3CL1 could be used as a target for depression treatment.
“thus, CX3CL1 could be used as a target for depression treatment. 186”
From Major depressive disorder: hypothesis, mechanism, prevention and treatment (2024) · cites this paper as [186]
The level of CX3CL1 in the serum is increased in patients with moderate-severe depression compared with healthy subjects.
“The level of CX3CL1 in the serum is increased in patients with moderate-severe depression compared with healthy subjects”
From Major depressive disorder: hypothesis, mechanism, prevention and treatment (2024) · cites this paper as [186]
MIP-1α is overexpressed in combination with fractalkine in patients with moderate to severe depression.
“Merendino et al., demonstrated overexpressed MIP-1α in combination with fractalkine in patients with moderate to severe depression [184].”
From Selected biomarkers of depression: what are the effects of cytokines and inflammation (2022) · cites this paper as [184]
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References 5 · Cited by 47
- Authors
- Merendino, R. A., Di Pasquale, G., De Luca, F., Di Pasquale, L., Ferlazzo, E., Martino, G., Palumbo, M. C., Morabito, F., & Gangemi, S.
- Affiliations
- University of Messina (IT)
- Azienda ospedaliera "Bianchi-Melacrino-Morelli" (IT)
- Corresponding author
- Gangemi, Sebastiano
- Venue
- Mediators of Inflammation
- Publisher
- Wiley
- Published
- 2004-01
- Volume
- 13
- Issue
- 3
- Pages
- 205-207
- ISSN
- 0962-9351 (ISSN-L)
- 1466-1861
- PMC
- PMC1781561
- OpenAlex
- W2095156987
- Cited by
- 47
- References
- 5
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 8 · 2021: 2 · 2020: 3 · 2019: 6 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 2
- FWCI
- 0.15
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Mediators of Inflammation (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- University of Messina, Medical School, Italy
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- fractalkine, macrophage inflammatory protein-1alpha, chemokines, inflammatory cytokines, serum biomarkers, neuroinflammation
- MeSH terms
- Depressive Disorder, Humans, Membrane Proteins, Reference Values, Macrophage Inflammatory Proteins, Chemokines, CX3C, Chemokine CCL3, Chemokine CCL4, Chemokine CX3CL1
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