Atrial natriuretic peptide, copeptin and adrenomedullin levels in polycystic ovary syndrome: a case-control study
Abstract
BACKGROUND: Polycystic ovary syndrome (PCOS) defined by the Rotterdam criteria does not take into account the unhealthy metabolic profile of the syndrome with increased insulin resistance (IR) and overweight favoring development of type 2 diabetes, hypertension and cardiovascular disease (CVD). We assess three vasoactive peptides associated with CVD in women with PCOS. METHOD: Plasma levels of mid-regional pro-atrial natriuretic peptide (MR-proANP), copeptin and mid-regional pro-adrenomedullin (MR-proADM) were measured in 98 PCOS patients and 46 age- and BMI-matched healthy women. RESULTS: We found no difference in levels of MR-proANP, copeptin and MR-proADM between the PCOS and control group. Multiple regression analyses on a combined group of PCOS and control subjects demonstrated an inverse correlation between MR-proANP and IR (measured by fasting C-peptide) and a positive correlations between copeptin and IR as well as MR-proADM and BMI. We found no association between peptide levels and different Rotterdam phenotypes. CONCLUSION: Plasma concentrations of MR-proANP, copeptin and MR-proADM were not increased in PCOS compared to age- and BMI-matched controls. Thus, these peptides cannot be used to detect increased risk of CVD in a young PCOS cohort.
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The relatively low endogenous testosterone levels in women with PCOS compared with men do not seem to have any major influence on MR-proANP levels.
“Based on these findings, the relatively low endogenous testosterone levels in women with PCOS compared with men do not seem to have any major influence on MR-proANP levels.”
From Effect of liraglutide on atrial natriuretic peptide, adrenomedullin, and copeptin in PCOS (2018) · cites this paper as [38]
In a previous cross-sectional study on 98 PCOS women, log2 MR-proANP and heart rate were significantly negatively correlated (β = −0.02, s.e. 0.004, r 0.43, P < 0.001).
“From a previous cross-sectional study on 98 PCOS women (38), we were able to extract data on MR-proANP and heart rate, and could reproduce the significant negative correlation, between log2 MR-proANP and heart rate (β = −0.02 (s.e. 0.004), r 0.43, P < 0.001) (unpublished data).”
From Effect of liraglutide on atrial natriuretic peptide, adrenomedullin, and copeptin in PCOS (2018) · cites this paper as [38]
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References 30 · Cited by 3
- Authors
- Frøssing, S., Nylander, M., Aziz, M., Skouby, S. O., Kistorp, C., & Faber, J.
- Affiliations
- University of Copenhagen (DK)
- Herlev Hospital (DK)
- Corresponding author
- Frøssing, Signe
- Venue
- Gynecological Endocrinology
- Publisher
- Informa UK Limited
- Published
- 2016-07-16
- Volume
- 33
- Issue
- 1
- Pages
- 30-33
- ISSN
- 0951-3590 (ISSN-L)
- 1473-0766
- OpenAlex
- W2473220193
- Cited by
- 3
- References
- 30
- Citations by year
- 2022: 1 · 2020: 1 · 2018: 1
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gynecological Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- polycystic ovary syndrome, atrial natriuretic peptide, copeptin, adrenomedullin, vasoactive peptides, insulin resistance, cardiovascular risk, body mass index, Rotterdam criteria, cardiovascular disease
- MeSH terms
- Adolescent, Adult, Female, Glycopeptides, Humans, Atrial Natriuretic Factor, Polycystic Ovary Syndrome, Case-Control Studies, Adrenomedullin, Young Adult
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