The cardiometabolic effect of current management of polycystic ovary syndrome: strategies of prevention and treatment
Abstract
Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder amongst women of reproductive age, which is characterized by reproductive and cardiometabolic disturbances with long-term health repercussions. Insulin resistance (IR), impaired glucose tolerance, type 2 diabetes mellitus (DM2), obesity and dyslipidemia occur more in women with PCOS than in age-comparable women without PCOS. Long term data regarding risks or benefits of medical intervention for metabolic dysfunction of PCOS are lacking. Therapies, such as oral contraceptives (OCPs) and anti-androgenic medications used to manage the reproductive manifestations of PCOS, may themselves be the cause of cardiometabolic perturbations. Hence, strategies regarding the management of reproductive issues in PCOS encompass a patient-specific tailored approach. Factors that influence the cardiometabolic side effects arising during treatment of the reproductive manifestations of PCOS (hirsutism/anovulation) are also discussed in this paper in order to build future strategies to minimize the overall cardiometabolic risk.
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The literature tends to only include overweight or obese individuals as study participants.
“the literature tends to only include overweight or obese individuals as study participants [18,39,43,47].”
From Moving beyond Weight: A Narrative Review of the Dietary and Lifestyle Management for Reducing Cardiometabolic Risk in Polycystic Ovary Syndrome (PCOS) (2023) · cites this paper as [43]
A large proportion of the literature is focused on weight loss for individuals with PCOS.
“A large proportion of the literature is focused on weight loss for individuals with PCOS [42,43,44,45]”
From Moving beyond Weight: A Narrative Review of the Dietary and Lifestyle Management for Reducing Cardiometabolic Risk in Polycystic Ovary Syndrome (PCOS) (2023) · cites this paper as [43]
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References 67 · Cited by 17
- Authors
- Baldani, D. P., Skrgatic, L., Ougouag, R., & Kasum, M.
- Affiliations
- Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Zagreb, School of Medicine, Clinical Hospital Centre Zagreb, Zagreb, Croatia;
- University of Zagreb (HR)
- University Hospital Centre Zagreb (HR)
- Corresponding author
- Kasum, Miro
- Venue
- Gynecological Endocrinology
- Publisher
- Informa UK Limited
- Published
- 2017-09-23
- Volume
- 34
- Issue
- 2
- Pages
- 87-91
- ISSN
- 0951-3590 (ISSN-L)
- 1473-0766
- OpenAlex
- W2757220620
- Cited by
- 17
- References
- 67
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 1
- FWCI
- 0.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gynecological Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Keywords
- polycystic ovary syndrome, cardiometabolic risk, insulin resistance, type 2 diabetes, obesity, dyslipidemia, impaired glucose tolerance, oral contraceptives, hirsutism, anovulation
- MeSH terms
- Healthy Lifestyle, Adult, Androgen Antagonists, Anovulation, Cardiovascular Diseases, Combined Modality Therapy, Contraceptives, Oral, Diabetes Mellitus, Type 2, Female, Fertility Agents, Male, Humans, Insulin Resistance, Obesity, Polycystic Ovary Syndrome, Risk Factors, Disease Progression, Dyslipidemias
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