Cited by 17Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsEndometriosis Research and Treatment

The cardiometabolic effect of current management of polycystic ovary syndrome: strategies of prevention and treatment

Baldani, Dinka Pavicic, Skrgatic, Lana, Ougouag, Roya, Kasum, Miro·2018·Gynecological Endocrinology

Abstract

Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder amongst women of reproductive age, which is characterized by reproductive and cardiometabolic disturbances with long-term health repercussions. Insulin resistance (IR), impaired glucose tolerance, type 2 diabetes mellitus (DM2), obesity and dyslipidemia occur more in women with PCOS than in age-comparable women without PCOS. Long term data regarding risks or benefits of medical intervention for metabolic dysfunction of PCOS are lacking. Therapies, such as oral contraceptives (OCPs) and anti-androgenic medications used to manage the reproductive manifestations of PCOS, may themselves be the cause of cardiometabolic perturbations. Hence, strategies regarding the management of reproductive issues in PCOS encompass a patient-specific tailored approach. Factors that influence the cardiometabolic side effects arising during treatment of the reproductive manifestations of PCOS (hirsutism/anovulation) are also discussed in this paper in order to build future strategies to minimize the overall cardiometabolic risk.

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Crossref · 10.1080/09513590.2017.1381681

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References 67 · Cited by 17

Authors
Baldani, D. P., Skrgatic, L., Ougouag, R., & Kasum, M.
Affiliations
  • Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Zagreb, School of Medicine, Clinical Hospital Centre Zagreb, Zagreb, Croatia;
  • University of Zagreb (HR)
  • University Hospital Centre Zagreb (HR)
Corresponding author
Kasum, Miro
Venue
Gynecological Endocrinology
Published
2017-09-23
Volume
34
Issue
2
Pages
87-91
ISSN
  • 0951-3590 (ISSN-L)
  • 1473-0766
OpenAlex
W2757220620
Cited by
17
References
67
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 1
FWCI
0.27
Type
journal article
Language
en
Open access
closed
Locations
  • Gynecological Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Keywords
polycystic ovary syndrome, cardiometabolic risk, insulin resistance, type 2 diabetes, obesity, dyslipidemia, impaired glucose tolerance, oral contraceptives, hirsutism, anovulation
MeSH terms
Healthy Lifestyle, Adult, Androgen Antagonists, Anovulation, Cardiovascular Diseases, Combined Modality Therapy, Contraceptives, Oral, Diabetes Mellitus, Type 2, Female, Fertility Agents, Male, Humans, Insulin Resistance, Obesity, Polycystic Ovary Syndrome, Risk Factors, Disease Progression, Dyslipidemias

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