The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Correlates of and barriers to ART adherence among adherence-challenged people living with HIV in southern India
Open accessAbstract
Suboptimal adherence to Antiretroviral Therapy (ART) regimens can lead to the development of drug resistance, virologic and clinical failure, and, on the community level, the spread of drug-resistant HIV. To design effective interventions, it is crucial to understand locally specific barriers to optimal adherence. Self-report data from a cross-sectional sample of 527 adherence-challenged people living with HIV (PLWH) in the South-Indian state of Karnataka showed that they took on average 68% of prescribed doses in the past month. Large majorities of participants encountered individual (95%), social/structural (88%), and clinic/regimen (80%) adherence barriers. Multivariate linear regression analyses of past month adherence showed that disclosure to all adults in the household was positively related to adherence, as was employing a larger number of adherence strategies, perceiving more benefits of ART, and having been on ART for longer. Fears of stigmatization upon disclosure of HIV-status to friends and people at work were negatively related to adherence. These results suggest that some barriers, especially individual-level barriers like forgetfulness are very common and can be targeted with relatively simple individual-level strategies. Other barriers, related to fear of stigma and lack of disclosure may require family- or community-level interventions.
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“HIV stigma manifestations, including enacted (experienced), anticipated (expected) and internalized stigma (endorsing stigmatizing attitudes),1 have adverse effects on the entire HIV care cascade. These range from delayed testing and care to low rates of antiretroviral treatment (ART) initiation and adherence, thereby impeding viral load suppression.3”
From An acceptance-based, intersectional stigma coping intervention for people with HIV who inject drugs—a randomized clinical trial (2023) · cites this paper as [3]
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Cited by
Luoma, J. B., Rossi, S. L., Sereda, Y., Pavlov, N., Toussova, O., Vetrova, M., Bendiks, S., Kiriazova, T., Krupitsky, E., Lioznov, D., et al. (2023) · The Lancet Regional Health - Europe · doi:10.1016/j.lanepe.2023.100611 · Cited by 16
Metadata
- Authors
- Heylen, E., Chandy, S., Shamsundar, R., Nair, S., Ravi Kumar, B. N., & Ekstrand, M. L.
- Affiliations
- University of California, San Francisco (US)
- St. John's National Academy of Health Sciences (IN)
- Karnataka State AIDS Prevention Society, Bangalore, India
- Corresponding author
- Heylen, Elsa
- Venue
- AIDS Care
- Publisher
- Informa UK Limited
- Published
- 2020-03-16
- Volume
- 33
- Issue
- 4
- Pages
- 486-493
- ISSN
- 0954-0121 (ISSN-L)
- 1360-0451
- PMC
- PMC7492371
- OpenAlex
- W3011683726
- Cited by
- 16
- References
- 3
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 2
- FWCI
- 0.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- AIDS Care (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Mental Health (R01 MH095659)
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
- Keywords
- antiretroviral therapy adherence, people living with HIV, barriers to adherence, HIV status disclosure, stigma, forgetfulness, adherence strategies, treatment duration, drug resistance, Karnataka
- MeSH terms
- Assessment of Medication Adherence, Adult, Cross-Sectional Studies, Depression, Fear, Female, Humans, India, Male, Middle Aged, Quality of Life, Social Support, HIV Infections, Drug Monitoring, Antiretroviral Therapy, Highly Active, Medication Adherence, Social Stigma
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
