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Effects of 15 Hz square wave magnetic fields on the voltage-gated sodium and potassium channels in prefrontal cortex pyramidal neurons
Abstract
Purpose: Although magnetic fields have significant effects on neurons, little is known about the mechanisms behind their effects. The present study aimed to measure the effects of magnetic fields on ion channels in cortical pyramidal neurons.Materials and methods: Cortical pyramidal neurons of Kunming mice were isolated and then subjected to 15 Hz, 1 mT square wave (duty ratio 50%) magnetic fields stimulation. Sodium currents (INa), transient potassium currents (IA) and delayed rectifier potassium currents (IK) were recorded by whole-cell patch clamp method.Results: We found that magnetic field exposure depressed channel current densities, and altered the activation kinetics of sodium and potassium channels. The inactivation properties of INa and IA were also altered.Conclusion: Magnetic field exposure alters ion channel function in neurons. It is likely that the structures of sodium and potassium channels were influenced by the applied field. Sialic acid, which is an important component of the channels, could be the molecule responsible for the reported results.
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“Notably, a study by Zheng et al. (2017) demonstrated that even at a much lower frequency—specifically, a 15 Hz square wave magnetic field—there were alterations in the activation kinetics of sodium and potassium channels in cortical pyramidal neurons.”
From Comparative analysis of energy transfer mechanisms for neural implants (2024) · cites this paper as Zheng et al., 2017
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Metadata
- Authors
- Zheng, Y., Dou, J.-R., Gao, Y., Dong, L., & Li, G.
- Affiliations
- Tiangong University (CN)
- Tianjin University (CN)
- Corresponding author
- Zheng, Yu
- Venue
- International Journal of Radiation Biology
- Publisher
- Informa UK Limited
- Published
- 2016-12-07
- Volume
- 93
- Issue
- 4
- Pages
- 449-455
- ISSN
- 0955-3002 (ISSN-L)
- 1362-3095
- OpenAlex
- W2560507888
- Cited by
- 16
- References
- 41
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 4 · 2019: 1 · 2018: 1
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Radiation Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Electromagnetic Fields and Biological Effects
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Magnetic and Electromagnetic Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Keywords
- magnetic field exposure, voltage-gated sodium channels, voltage-gated potassium channels, sodium current, transient potassium current, delayed rectifier potassium current, channel inactivation kinetics, sialic acid, ion channel function
- MeSH terms
- Animals, Cells, Cultured, Dose-Response Relationship, Radiation, Male, Potassium, Radiation Dosage, Sodium, Ion Channel Gating, Prefrontal Cortex, Pyramidal Cells, Mice, KCNQ1 Potassium Channel, Magnetic Fields, Voltage-Gated Sodium Channels
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