Born to be anxious: neuroendocrine and genetic correlates of trait anxiety in HAB rats
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This review summarises behavioural, neuroendocrine, and genetic characteristics of Wistar rats bred for either high (HAB) or low (LAB) anxiety-related behaviour. Compared to LABs, HAB animals show signs of extreme trait anxiety in a variety of behavioural tests; they further prefer passive coping strategies, indicative of a genetically linked depression-like behaviour, and show signs of increased stress vulnerability. All behavioural parameters associated with trait anxiety are robust and consistent. Resembling psychiatric patients, HAB rats respond to exposure to ethologically relevant stressors with a hyper-reactivity of the hypothalamic-pituitary-adrenal axis and show a pathological outcome of the combined dexamethasone/corticotropin-releasing hormone (Dex/CRH) challenge test. Experimental evidence indicates that over-expression and -release of vasopressin in the hypothalamic paraventricular nucleus is responsible for these behavioural and neuroendocrine phenomena, making the neuropeptide gene a candidate gene of trait anxiety/depression. Indeed, preliminary molecular genetic approaches succeeded in identifying polymorphisms in the promoter structure of the vasopressin gene. This may have implications for understanding the molecular basis for individual variations in trait anxiety and for psychopathology.
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From Anxiety, depression, and the microbiome: A role for gut peptides (2018) · cites this paper as [375]
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References 42 · Cited by 122
Research works printed but not linked: 1
- Bakshi, V.P. and Kalin, N.H. (2002) Animal models and endophenotypes of anxiety and stress disorders, In: Davis, K.L., Charney, D., Coyle, J.T. and Nemeroff, C., eds, Neuropsychopharmacology: The 5th Generation of Progress (Lippincott Williams & Wilkins, New York), pp 883-900.
- Authors
- Landgraf, R., & Wigger, A.
- Affiliations
- Max Planck Society (DE)
- Max Planck Institute of Psychiatry (DE)
- Corresponding author
- Landgraf, R.
- Venue
- Stress
- Publisher
- Informa UK Limited
- Published
- 2003-01
- Volume
- 6
- Issue
- 2
- Pages
- 111-119
- ISSN
- 1025-3890 (ISSN-L)
- 1607-8888
- OpenAlex
- W2023824822
- Cited by
- 122
- References
- 42
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 3 · 2022: 2 · 2020: 2 · 2019: 2 · 2018: 6 · 2017: 3 · 2016: 4 · 2015: 4 · 2014: 10 · 2013: 5 · 2012: 5
- FWCI
- 4.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Stress (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- trait anxiety, anxiety-like behavior, depression-like behavior, stress vulnerability, hypothalamic-pituitary-adrenal axis, vasopressin, paraventricular nucleus, candidate genes, individual differences in anxiety, stress reactivity
- MeSH terms
- Animals, Anxiety, Disease Models, Animal, Neurosecretory Systems, Rats, Wistar, Rats
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