The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.
α-Glucosidase and α-amylase inhibitors from seed oil: A review of liposoluble substance to treat diabetes
Abstract
One of the effective managements of diabetes mellitus, in particular, noninsulin-dependent diabetes mellitus, is to retard the absorption of glucose by inhibition of carbohydrate hydrolyzing enzymes, such as α-glucosidase and α-amylase, in the digestive organs. Currently, there is renewed interest in plant-based medicines and functional foods modulating physiological effects in the inhibition of α-glucosidase and α-amylase. Accordingly, inhibitors of α-glucosidase or α-amylase derived from various sources have also been isolated, and majority of phenolic compounds and their effects have been investigated in animals as well. As such, when the presence of α-glucosidase inhibitor in many foodstuffs was screened for, we found that vegetable seed oil also strongly inhibited α-glucosidase and α-amylase. Seed oil is an important source of liposoluble constituents with potential for inhibition of these enzymes, hence can also be used as therapeutic or functional food sources. Therefore, this review is aimed at highlighting the main liposoluble classes of α-glucosidase and α-amylase inhibitors, but it is not intended to be an exhaustive review on the subject.
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“Besides, α-Glucosidase Inhibitors contribute for prolonging the overall carbohydrate digestion duration and reducing the rate of glucose absorption (189).”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [189]
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Cites
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Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments
Wang, M., Tan, Y., Shi, Y., Wang, X., Liao, Z., & Wei, P. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00568 · Cited by 231
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The inhibitory effects of flavonoids on α-amylase and α-glucosidase
Zhu, J., Chen, C., Zhang, B., & Huang, Q. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1548428 · Cited by 196
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Metadata
- Authors
- Teng, H., & Chen, L.
- Affiliations
- Fujian Agriculture and Forestry University (CN)
- Corresponding author
- Chen, Lei
- ORCID
- Teng, Hui
- Venue
- Critical Reviews in Food Science and Nutrition
- Publisher
- Informa UK Limited
- Published
- 2017-05-25
- Volume
- 57
- Issue
- 16
- Pages
- 3438-3448
- ISSN
- 1040-8398 (ISSN-L)
- 1549-7852
- OpenAlex
- W2276117594
- Cited by
- 162
- References
- 107
- Citations by year
- 2026: 14 · 2025: 19 · 2024: 20 · 2023: 19 · 2022: 22 · 2021: 17 · 2020: 27 · 2019: 13 · 2018: 5 · 2017: 3
- FWCI
- 8.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Reviews in Food Science and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Bioactive natural compounds
- Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
- Keywords
- alpha-glucosidase inhibitors, alpha-amylase inhibitors, seed oil, type 2 diabetes, glucose absorption, carbohydrate hydrolysis, phenolic compounds, functional foods, plant-derived drugs, enzyme inhibition
- MeSH terms
- alpha-Amylases, Animals, Blood Glucose, Diabetes Mellitus, Type 2, Enzyme Inhibitors, Humans, Intestinal Absorption, Plant Extracts, Glycoside Hydrolase Inhibitors
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