Vitamin D and pancreas: The role of sunshine vitamin in the pathogenesis of diabetes mellitus and pancreatic cancer
Abstract
Increasing evidence suggests that vitamin D exerts multiple effects beyond bone and calcium metabolism. Vitamin D seems to play a role in pancreatic disease, including type 1 and type 2 diabetes mellitus as well as pancreatic cancer. Vitamin D's immune-modulatory action suggests that it could help prevent type 1 diabetes. In type 2 diabetes, vitamin D may influence β-cell function, insulin sensitivity, and systematic inflammation-all characteristic pathways of that disease. Data from observational studies correlated vitamin D deficiency with risk of type 1 and type 2 diabetes. Prospective and ecological studies of pancreatic cancer incidence generally support a beneficial effect of higher 25-hydroxyvitamin D concentration as well as inverse correlations between UVB dose or exposure and incidence and/or mortality rate of pancreatic cancer. This review discusses the literature regarding vitamin D's role in risk of diabetes and pancreatic cancer. The results to date generally satisfy Hill's criteria for causality regarding vitamin D and incidence of these pancreatic diseases. However, large randomized, blinded, prospective studies are required to more fully evaluate the potential therapeutic role of vitamin D in preventing pancreatic diseases.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Low vitamin D status is associated with increased blood pressure, dyslipidemia, impaired insulin metabolism, sleep disturbances, thus increasing the risk of cardiovascular atherosclerosis.
“Therefore, low vitamin D status has been associated with increased BP [139, 140], dyslipidemia [139, 140], impaired insulin metabolism [138], sleep disturbances [141, 142], thus increasing the risk of cardiovascular atherosclerosis [139, 140].”
From Mediterranean Diet and Obesity-related Disorders: What is the Evidence? (2022) · cites this paper as [138]
The citation lists haven’t been fetched yet
References 160 · Cited by 113
- Authors
- Altieri, B., Grant, W. B., Della Casa, S., Orio, F., Pontecorvi, A., Colao, A., Sarno, G., & Muscogiuri, G.
- Affiliations
- Università Cattolica del Sacro Cuore (IT)
- Sunlight Nutrition and Health Research Center (US)
- Institute of Medical Pathology, Division of Endocrinology and Metabolic Diseases, Catholic University of the Sacred Heart, Rome, Italy
- Parthenope University of Naples (IT)
- Federico II University Hospital (IT)
- AOU San Giovanni di Dio e Ruggi d'Aragona (IT)
- Ios and Coleman Medicina Futura Medical Center, Naples, Italy
- Corresponding author
- Muscogiuri, Giovanna
- ORCID
- Venue
- Critical Reviews in Food Science and Nutrition
- Publisher
- Informa UK Limited
- Published
- 2017-05-25
- Volume
- 57
- Issue
- 16
- Pages
- 3472-3488
- ISSN
- 1040-8398 (ISSN-L)
- 1549-7852
- OpenAlex
- W2317963951
- Cited by
- 113
- References
- 160
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 10 · 2023: 19 · 2022: 12 · 2021: 24 · 2020: 9 · 2019: 3 · 2018: 10 · 2017: 8 · 2016: 3
- FWCI
- 7.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Reviews in Food Science and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (Parthenope University of Naples) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Keywords
- vitamin D, diabetes mellitus, type 1 diabetes, type 2 diabetes, pancreatic cancer, 25-hydroxyvitamin D, UVB exposure, vitamin D deficiency, beta-cell function, insulin sensitivity, systemic inflammation, immunomodulation, disease prevention
- MeSH terms
- Diabetes Mellitus, Type 2, Humans, Pancreatic Neoplasms, Prospective Studies, Sunlight, Vitamin D, Vitamin D Deficiency, Vitamins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
