The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.
Nucleotide Pyrophosphatases/Phosphodiesterases on the Move
Abstract
Nucleotide pyrophosphatases/phosphodiesterases (NPPs) release nucleoside 5'-monophosphates from nucleotides and their derivatives. They exist both as membrane proteins, with an extracellular active site, and as soluble proteins in body fluids. The only well-characterized NPPs are the mammalian ecto-enzymes NPP1 (PC-1), NPP2 (autotaxin) and NPP3 (B10; gp130(RB13-6)). These are modular proteins consisting of a short N-terminal intracellular domain, a single transmembrane domain, two somatomedin-B-like domains, a catalytic domain, and a C-terminal nuclease-like domain. The catalytic domain of NPPs is conserved from prokaryotes to mammals and shows remarkable structural and catalytic similarities with the catalytic domain of other phospho-/sulfo-coordinating enzymes such as alkaline phosphatases. Hydrolysis of pyrophosphate/phosphodiester bonds by NPPs occurs via a nucleotidylated threonine. NPPs are also known to auto(de)phosphorylate this active-site threonine, a process accounted for by an intrinsic phosphatase activity, with the phosphorylated enzyme representing the catalytic intermediate of the phosphatase reaction. NPP1-3 have been implicated in various processes, including bone mineralization, signaling by insulin and by nucleotides, and the differentiation and motility of cells. While it has been established that most of these biological effects of NPPs require a functional catalytic site, their physiological substrates remain to be identified.
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Cites
A hidden Markov model for predicting transmembrane helices in protein sequences.
Sonnhammer, E. L. L., von HEIJNE, G., & Krogh, A. (1998) · PubMed · Cited by 2,505
The PROSITE database, its status in 1995
Bairoch, A. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.1.189 · Cited by 1,924
Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides
Dubyak, G. R., & el-Moatassim, C. (1993) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1993.265.3.c577 · Cited by 1,237
The PROSITE database, its status in 1999
Hofmann, K., Bucher, P., Falquet, L., & Bairoch, A. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.1.215 · Cited by 1,092
Ion motive ATPases. I. Ubiquity, properties, and significance to cell function
Pedersen, P. L., & Carafoli, E. (1987) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(87)90071-5 · Cited by 962
CRYSTAL STRUCTURES OF THE HELIX-LOOP-HELIX CALCIUM-BINDING PROTEINS
Strynadka, N. C. J., & James, M. N. G. (1989) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.58.070189.004511 · Cited by 860
Jones, D. T., Taylor, W. R., & Thornton, J. M. (1994) · Biochemistry · doi:10.1021/bi00176a037 · Cited by 779
Stracke, M. L., Krutzsch, H. C., Unsworth, E. J., Arestad, A., Cioce, V, Schiffmann, E., & Liotta, L. A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45911-x · Cited by 590
Structure and Biological Role of Vitronectin
Preissner, K. T. (1991) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.07.110191.001423 · Cited by 486
Cell migration: regulation of force on extracellular-matrix-integrin complexes
Sheetz, M. P., Felsenfeld, D. P., & Galbraith, C. G. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(98)80005-6 · Cited by 449
Cited by
Tokumura, A., Majima, E., Kariya, Y., Tominaga, K., Kogure, K., Yasuda, K., & Fukuzawa, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205623200 · Cited by 731
NPP-type ectophosphodiesterases: unity in diversity
Stefan, C., Jansen, S., & Bollen, M. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.08.005 · Cited by 373
Self-citationEl Husseini, D., Boulanger, M.-C., Mahmut, A., Bouchareb, R., Laflamme, M.-H., Fournier, D., Pibarot, P., Bossé, Y., & Mathieu, P. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.02.014 · Cited by 150
ATP acts as a survival signal and prevents the mineralization of aortic valve
Côté, N., El Husseini, D., Pépin, A., Guauque-Olarte, S., Ducharme, V., Bouchard-Cannon, P., Audet, A., Fournier, D., Gaudreault, N., Derbali, H., et al. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2012.02.003 · Cited by 95
Tokumura, A., Kume, T., Taira, S., Yasuda, K., & Kanzaki, H. (2009) · Molecular Human Reproduction · doi:10.1093/molehr/gap017 · Cited by 30
Metadata
- Authors
- Bollen, M., Gijsbers, R., Ceulemans, H., Stalmans, W., & Stefan, C.
- Venue
- Critical Reviews in Biochemistry and Molecular Biology
- Publisher
- Informa UK Limited
- Published
- 2000-01
- Volume
- 35
- Issue
- 6
- Pages
- 393-432
- ISSN
- 0045-6411 (ISSN-L)
- 1040-9238
- 1549-7798
- OpenAlex
- W2022545583
- Cited by
- 277
- References
- 79
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- closed
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