3D Matrices for Anti-Cancer Drug Testing and Development
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In general, the proliferation rate of cells grown in 3D culture better represents the growth of tumors in vivo compared to those cultured in 2D.
“In general, the proliferation rate of cells grown in 3D culture better represent the growth of tumors in vivo compared to those cultured in an unnatural 2D environment. 17”
From Three-dimensional cell culture systems and their applications in drug discovery and cell-based biosensors (2014) · cites this paper as [17]
Differential gene and/or protein expression in 2D and 3D cell cultures is often the reason that cells cultured in 3D systems behave differently in growth and proliferation, migration and invasion, morphology, and drug sensitivity compared to 2D cells.
“The differential gene and/or protein expression in 2D and 3D cell cultures is often the reason that the cells cultured in 3D systems behave differently in many cellular processes, including growth and proliferation, migration and invasion, morphology, and drug sensitivity in comparison to the cells cultured in 2D. 17”
From Three-dimensional cell culture systems and their applications in drug discovery and cell-based biosensors (2014) · cites this paper as [17]
A variety of cell lines showed reduced proliferation rate in 3D cultures compared to those cultured in 2D.
“A variety of cell lines showed reduced proliferation rate in 3D cultures compared to those cultured in 2D. 17,27-31”
From Three-dimensional cell culture systems and their applications in drug discovery and cell-based biosensors (2014) · cites this paper as [17]
Various cancer cell lines grown in 2D and 3D culture often display different gene expression profiles, especially many genes that play a role in proliferation, angiogenesis, migration, invasion, and chemosensitivity.
“Various cancer cell lines grown in 2D and 3D culture often display different gene expression profiles, especially many genes that play a role in proliferation, angiogenesis, migration, invasion, and chemosensitivity. 17,40”
From Three-dimensional cell culture systems and their applications in drug discovery and cell-based biosensors (2014) · cites this paper as [17]
Proliferation rates of cells cultured in 3D and 2D are usually different and are cell line and matrix dependent.
“The proliferation rates of cells cultured in 3D and 2D are usually different, and are cell line and matrix dependent.”
From Three-dimensional cell culture systems and their applications in drug discovery and cell-based biosensors (2014) · cites this paper as [17]
The citation lists haven’t been fetched yet
References 71 · Cited by 130
- Authors
- Gurski, L. A., Petrelli, N. J., Jia, X., & Farach-Carson, M. C.
- Affiliations
- University of Delaware (US)
- Venue
- Oncology Issues
- Publisher
- SLACK, Inc.
- Published
- 2010-01
- Volume
- 25
- Issue
- 1
- Pages
- 20-25
- ISSN
- 1046-3356 (ISSN-L)
- 2573-1777
- OpenAlex
- W2320375598
- Cited by
- 130
- References
- 71
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2023: 14 · 2022: 16 · 2021: 12 · 2020: 12 · 2019: 12 · 2018: 13 · 2017: 10 · 2016: 8 · 2015: 4 · 2014: 5 · 2013: 5 · 2012: 6
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncology Issues (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- drug development, 3D cell culture, cancer cell models
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
