A preliminary trial: double-blind comparison of nefazodone, bupropion-SR, and placebo in the treatment of cannabis dependence.
Open accessAbstract
The present study investigated the efficacy of nefazodone and bupropion‐sustained release for treating cannabis dependence. A double‐blind, placebo‐controlled, piggy back design was employed to assess if nefazodone and bupropion‐sustained release increased the probability of abstinence from cannabis and reduced the severity of cannabis dependence and cannabis withdrawal symptoms during a 13‐week outpatient treatment program. One‐hundred and six participants (Mean = 32 years; females n = 25) were randomized to one of three medication conditions (nefazodone, bupropion‐sustained release, or placebo) and participated in a weekly, individually based coping skills therapy program. Results indicated an increased probability of achieving abstinence over the course of treatment and a decrease in the severity of cannabis dependence and the withdrawal symptom of irritability. There were no significant effects demonstrated for nefazodone and bupropion‐sustained release on cannabis use or cannabis withdrawal symptoms. The results indicate nefazodone and bupropion‐sustained release may have limited efficacy in treating cannabis dependence.
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References 59 · Cited by 89
Research works printed but not linked: 3
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- Authors
- Carpenter, K. M., McDowell, D., Brooks, D. J., Cheng, W. Y., & Levin, F. R.
- Affiliations
- New York State Psychiatric Institute (US)
- Corresponding author
- Levin, Frances R.
- Venue
- The American Journal on Addictions
- Publisher
- Wiley
- Published
- 2009-01-02
- Volume
- 18
- Issue
- 1
- Pages
- 53-64
- ISSN
- 1055-0496 (ISSN-L)
- 1521-0391
- PMC
- PMC2759381
- OpenAlex
- W2119537241
- Cited by
- 89
- References
- 59
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 12 · 2017: 3 · 2016: 12 · 2015: 7 · 2014: 7 · 2013: 6 · 2012: 7
- FWCI
- 4.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal on Addictions (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Public Health Service (K02 00465)
- National Institute on Drug Abuse (R01DA13191, K23DA021850, R01DA013191)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- cannabis use disorder, nefazodone, bupropion sustained release, abstinence, irritability, pharmacotherapy, outpatient care
- MeSH terms
- Adult, Marijuana Abuse, Delayed-Action Preparations, Double-Blind Method, Female, Humans, Male, Piperazines, Placebos, Severity of Illness Index, Substance Withdrawal Syndrome, Triazoles, Bupropion, Outcome Assessment, Health Care, Antidepressive Agents, Second-Generation
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