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Aloe vera: A review of toxicity and adverse clinical effects
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“These actions result in increased water content in the intestinal lumen, producing a laxative effect that has been exploited for constipation treatment in IBS adults, although concerns about potential long-term side effects have been raised [90].”
From Natural Remedies for Irritable Bowel Syndrome: A Comprehensive Review of Herbal-Based Therapies (2025) · cites this paper as [90]
In the citing paper
“Other agents, including Aloe vera, flavonoids, St John’s wort, and ginger, exhibit mixed or inconsistent results, reflecting heterogeneity in study designs and underlying mechanisms.”
From Plant-Derived Treatments for IBS: Clinical Outcomes, Mechanistic Insights, and Their Position in International Guidelines (2026) · cites this paper as [76]
In the citing paper
“These actions increase intestinal motility and paracellular permeability, thereby increasing water content in the intestinal lumen, and Aloe vera has therefore been used as a treatment option for IBS-C in adults [76].”
From Plant-Derived Treatments for IBS: Clinical Outcomes, Mechanistic Insights, and Their Position in International Guidelines (2026) · cites this paper as [76]
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Cites
Tanaka, M., Yamamoto, Y., Misawa, E., Nabeshima, K., Saito, M., Yamauchi, K., Abe, F., & Furukawa, F. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000454718 · Cited by 1,092
Research works printed but not linked: 98
- Barnes PM, Natl Health Stat Report., 12, 1
- Nahin RL, Natl Health Stat Report., 18, 1
- Cosmetic Ingredient Review Expert Panel (CIR), Int J Toxicol., 26, 1
- 10.1080/10408390802544454 · DOI
- 10.1080/10590500600614303 · DOI · Paper page
- 10.1016/j.intimp.2004.07.006 · DOI
- 10.1016/0378-8741(86)90085-1 · DOI
- Atherton P., Nurs Stand., 12, 49, 10.7748/ns.12.41.49.s40 · DOI
- 10.1016/S0378-8741(99)00085-9 · DOI
- 10.1016/j.amjsurg.2010.06.017 · DOI
- Foster M, Herbal Medicine: Biomolecular and Clinical Aspects
- Vogler BK, Br J Gen Pract., 49, 823
- 10.1111/j.1750-3841.2011.02452.x · DOI
- US Food and Drug Administration, Fed Regist., 67, 31125
- 10.1016/S1470-2045(13)70329-2 · DOI
- International Agency for Research on Cancer, Some Drugs and Herbal Products (Volume 108)
- 10.1016/j.toxlet.2006.11.015 · DOI
- 10.1039/C4TX00053F · DOI
- 10.1078/0944-7113-00044 · DOI
- Dhar ML, Indian J Exp Biol., 6, 232
- 10.3109/01480545.2013.834356 · DOI
- Zhou Y, Wei Sheng Yan Jiu., 32, 590
- 10.1002/ptr.2650030107 · DOI
- Boudreau MD, Natl Toxicol Program Tech Rep Ser., 577, 1
- 10.1016/j.fct.2013.03.002 · DOI
- Sehgal I, J Toxicol., 802453, 10.1155/2013/802453 · DOI
- 10.1016/0165-1161(82)90007-3 · DOI
- 10.1093/toxsci/kfs275 · DOI
- 10.1016/j.fct.2007.09.107 · DOI
- 10.1111/j.1750-3841.2009.01070.x · DOI
- 10.1080/10590501.2013.824206 · DOI
- National Toxicology Program, Natl Toxicol Program Tech Rep Ser., 553, 7
- 10.1080/13880200701215307 · DOI
- 10.1345/aph.1E098 · DOI
- Luyckx VA, Am J Kidney Dis., 39, E13
- 10.1080/10590500903585416 · DOI
- 10.3748/wjg.v11.i2.303 · DOI
- 10.1016/j.ejim.2006.04.017 · DOI
- 10.1345/aph.1K132 · DOI
- 10.1157/13125590 · DOI
- 10.3346/jkms.2010.25.3.492 · DOI · Paper page
- 10.4166/kjg.2014.64.1.54 · DOI
- 10.1002/(SICI)1099-1565(199807/08)9:4<186::AID-PCA406>3.0.CO;2-# · DOI
- 10.1002/pca.682 · DOI
- 10.1111/j.1095-8339.1985.tb00378.x · DOI
- 10.1021/jf010179c · DOI
- 10.1016/S0022-5347(05)00005-4 · DOI
- 10.1016/j.fct.2004.03.002 · DOI
- 10.1038/sj.bjp.0704342 · DOI
- Popadic D, J Cosmet Sci., 63, 297
- 10.1016/j.tiv.2007.10.013 · DOI
- 10.1016/j.yrtph.2014.05.001 · DOI
- 10.1042/bst0051489 · DOI
- 10.1016/0165-1218(90)90002-J · DOI
- 10.1016/j.mrgentox.2009.06.004 · DOI
- 10.1016/0165-1218(95)00084-4 · DOI
- 10.1016/S0165-1218(96)90105-6 · DOI
- 10.1016/S0304-4165(99)00064-1 · DOI
- 10.1093/toxsci/kfq282 · DOI
- 10.1016/j.canlet.2005.07.036 · DOI
- 10.1021/tx100248s · DOI
- Wolfle D, Cancer Res., 50, 6540
- 10.1093/carcin/11.5.799 · DOI
- National Toxicology Program, Natl Toxicol Program Tech Rep Ser., 493, 1
- Strickland FM, Photochem Photobiol., 72, 407
- Fantus B., J Am Pharm Assoc., 11, 616
- 10.1046/j.1365-2036.1999.00468.x · DOI
- Cholongitas E, Eur J Intern Med., 16, 59
- 10.1055/s-0028-1109056 · DOI
- 10.1136/pgmj.65.762.216 · DOI
- 10.1016/S0144-8617(98)00163-5 · DOI
- 10.3390/molecules13081599 · DOI · Paper page
- Wang Y-T, Subtropical Plant Sci., 47, 34
- 10.1016/j.carres.2005.02.016 · DOI
- 10.1016/S0008-6215(00)85211-8 · DOI
- 10.1002/ptr.2650070706 · DOI
- 10.1016/S0041-0101(97)00020-2 · DOI
- Asgharzade S, Iran J Basic Med Sci., 38, 967
- 10.1016/j.fct.2013.01.012 · DOI
- 10.1002/(SICI)1099-1573(199805)12:3<183::AID-PTR219>3.0.CO;2-Q · DOI
- 10.1002/ptr.1022 · DOI
- 10.1016/j.jep.2005.06.013 · DOI
- 10.1016/j.yrtph.2010.01.002 · DOI
- Visuthikosol V, J Med Assoc Thai., 78, 403
- Reddy RL, Quintessence Int., 43, 793
- 10.1055/s-0031-1280474 · DOI
- Babaee N, Dent Res J (Isfahan)., 9, 381
- 10.1001/archderm.1980.01640330102026 · DOI
- 10.1111/j.1600-0536.2007.01118.x · DOI
- Hunter D, Cutis., 47, 193
- 10.3945/jn.110.133025 · DOI
- Guo L, Handbook of Systems Toxicology, 2011, 407
- Ceccaroli C, Pulliero A, Geretto M, Izzotti A. Molecular fingerprints of environmental carcinogens in human cancer.J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2015;33:188–228. · DOI
- Ning B, Su Z, Mei N, Hong H, Deng H, Shi L, Fuscoe JC, Tolleson WH. Toxicogenomics and cancer susceptibility: advances with next-generation sequencing.J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2014;32:121–158. · DOI
- Ruan J, Gao H, Li N, Xue J, Chen J, Ke C, Ye Y, Fu PP, Zheng J, Wang J, Lin G. Blood Pyrrole-Protein Adducts-A Biomarker of Pyrrolizidine Alkaloid-Induced Liver Injury in Humans.J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2015;33:404–421. · DOI
- 10.1053/j.gastro.2015.02.050 · DOI
- 10.1016/j.amjmed.2013.09.016 · DOI
- 10.1093/toxsci/kft072 · DOI
Cited by
Biomedical applications of Aloe vera
Gao, Y., Kuok, K. I., Jin, Y., & Wang, R. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1496320 · Cited by 170
Interactions between Food and Drugs, and Nutritional Status in Renal Patients: A Narrative Review
D’Alessandro, C., Benedetti, A., Di Paolo, A., Giannese, D., & Cupisti, A. (2022) · Nutrients · doi:10.3390/nu14010212 · Cited by 66
Comprehensive review of hepatotoxicity associated with traditional Indian Ayurvedic herbs
Philips, C. A., Ahamed, R., Rajesh, S., George, T., Mohanan, M., & Augustine, P. (2020) · World Journal of Hepatology · doi:10.4254/wjh.v12.i9.574 · Cited by 57
Natural Remedies for Irritable Bowel Syndrome: A Comprehensive Review of Herbal-Based Therapies
Abalo, R., Gallego-Barceló, P., & Gabbia, D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199345 · Cited by 5
Pastras, P., Aggeletopoulou, I., Bali, M., & Triantos, C. (2026) · Nutrients · doi:10.3390/nu18020183 · Cited by 1
Metadata
- Authors
- Guo, X., & Mei, N.
- Venue
- Journal of Environmental Science and Health, Part C
- Publisher
- Informa UK Limited
- Published
- 2016-03-17
- Volume
- 34
- Issue
- 2
- Pages
- 77-96
- ISSN
- 1059-0501
- 1532-4095
- Cited by
- 210
- References
- 1
- Language
- en
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.