Vitamin E ingestion improves several immune functions in elderly men and women
Abstract
The effects of diet supplementation with the antioxidant vitamin E (200 mg daily) on several blood neutrophil, lymphocyte and natural killer cell functions have been investigated in healthy elderly men and women before supplementation, after 3 months of supplementation and 6 months after the end of supplementation (post-supplementation). In parallel, samples of healthy adult men and women were used as age controls. In elderly men and women, an impairment of immune functions was observed in comparison with the respective adult controls and the intake of vitamin E resulted in a significant enhancement of immune parameters in both elderly men and women, bringing their values close to those in the adults. These effects were not found in post-supplementation samples in several but not in all functions. The present findings suggest that supplementation with vitamin E can produce an improvement of immune functions and therefore of health in aged people.
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Vitamin supplementation studies in older adults have demonstrated a role for vitamin E in the production of IL-2 and activation-induced T cell proliferation in naïve but not memory T cells.
“Vitamin supplementation studies in older adults have demonstrated a role for vitamin E in the production of IL-2 as well as the activation induced T cell proliferation in naïve but not in memory T cells (78, 113–115).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [114]
Supplementation with vitamin E in older people has been shown to significantly improve NK cytotoxic activity, neutrophil chemotaxis and the phagocytic response, and enhance mitogen-induced lymphocyte proliferation and IL-2 production.
“Supplementation with vitamin E in older people has been shown to significantly improve NK cytotoxic activity, neutrophil chemotaxis and the phagocytic response, and enhance mitogen-induced lymphocyte proliferation and IL-2 production [123].”
From Immune function and micronutrient requirements change over the life course (2018) · cites this paper as [123]
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References 51 · Cited by 124
- Authors
- De la Fuente, M., Hernanz, A., Guayerbas, N., Manuel Victor, V., & Arnalich, F.
- Affiliations
- Universidad Complutense de Madrid (ES)
- Hospital Universitario La Paz (ES)
- ORCID
- Arnalich, Francisco
- Venue
- Free Radical Research
- Publisher
- Informa UK Limited
- Published
- 2008-01
- Volume
- 42
- Issue
- 3
- Pages
- 272-280
- ISSN
- 1029-2470 (ISSN-L)
- 1071-5762
- OpenAlex
- W2018263946
- Cited by
- 124
- References
- 51
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 10 · 2023: 8 · 2022: 16 · 2021: 15 · 2020: 20 · 2019: 8 · 2018: 5 · 2017: 4 · 2016: 1 · 2015: 1 · 2014: 4 · 2013: 4 · 2012: 6
- FWCI
- 3.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministerio de Economía y Competitividad
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
- Keywords
- vitamin E, dietary supplementation, immune function, aging, older adults, neutrophils, lymphocytes, natural killer cells, antioxidants, age-related immune decline
- MeSH terms
- Aged, Antioxidants, Chemotaxis, Female, Humans, Immune System, Interleukin-2, Lymphocytes, Male, Middle Aged, Neutrophils, Sex Factors, Vitamin E, Dietary Supplements, Cell Proliferation
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