DNA damage and protein oxidation associated with ageing correlate with cognitive dysfunction in a Malaysian population
Abstract
Ageing is associated with increased oxidative stress accompanied by cognitive decline. The aim of this study was to evaluate oxidative stress biomarkers and their possible relationship with cognitive performances during ageing among the Malay population. Approximately 160 healthy Malay adults aged between 28 and 79 years were recruited around Selangor and Klang Valley. Cognitive function was assessed by Montreal Cognitive Assessment (MoCA), forward digit span (FDS), backward digit span (BDS), digit symbol, Rey Auditory Verbal Learning Test immediate recalled [RAVLT(I)] and delayed recalled [RAVLT(D)], and visual reproduction immediate recalled (VR-I) and delayed recalled (VR-II). DNA damage, plasma protein carbonyl and malondialdehyde (MDA) levels were also determined. Cognitive function test showed significant lower scores of MoCA, BDS, RAVLT(I), RAVLT(D), digit symbol, VR-I, and VR-II in the older age group (60 years old) compared with the 30-, 40-, and 50-year-old group. The extent of DNA damage was sequential with age: 60 > 50 > 40 > 30, whereas protein carbonyl was higher in 40-, 50-, and 60-year-old groups compared with the youngest group (30 years old). However, the MDA level was observed unchanged in all age groups. Approximately 21.88% of the participants had cognitive impairment. Multiple logistic regression analysis revealed that DNA damage and protein carbonyl levels are predictors for cognitive impairment in healthy Malays. In conclusion, cognitive decline occurr…
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All other recent studies revealed higher concentrations of protein carbonyls in adults and elderly compared to younger individuals.
“all other recent studies revealed higher concentrations of protein carbonyls in adults and elderly compared to younger individuals (Table 4)”
From Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases (2021) · cites this paper as [234]
Plasma MDA levels do not differ among four age groups (28-34, 35-45, 47-54, and 57-79 years), as measured by HPLC.
“| Aging | Plasma | Healthy individuals divided into 4 groups: group 30 (28–34 years), group 40 (35–45 years), group 50 (47–54 years) and group above 60 (57–79 years) | HPLC | No differences between the groups | [234] |”
From Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases (2021) · cites this paper as [234]
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References 60 · Cited by 7
- Authors
- Abdul Sani, N. F., Ahmad Damanhuri, M. H., Amir Hamzah, A. I. Z., Abu Bakar, Z. H., Tan, J.-K., Nor Aripin, K. N., Mohd Rani, M. D., Noh, N. A., Shamaan, N. A., Razali, R., Mohd Yusof, Y. A., Mazlan, M., Makpol, S., & Wan Ngah, W. Z.
- Affiliations
- Department of Biochemistry, Universiti Kebangsaan Malaysia Medical Center Jalan Yaacob Latif, Kuala Lumpur, Malaysia;
- University Kebangsaan Malaysia Medical Centre (MY)
- Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia, Kuala Lumpur, Malaysia;
- Universiti Sains Islam Malaysia (MY)
- Universiti Teknologi MARA (MY)
- Corresponding author
- Makpol, Suzana
- Venue
- Free Radical Research
- Publisher
- Informa UK Limited
- Published
- 2018-09-02
- Volume
- 52
- Issue
- 9
- Pages
- 1000-1009
- ISSN
- 1029-2470 (ISSN-L)
- 1071-5762
- OpenAlex
- W2887572333
- Cited by
- 7
- References
- 60
- Citations by year
- 2026: 2 · 2023: 1 · 2021: 4
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Malaysia (LRGS/BU/2012/UKM-UKM/K/04, DIP-2015-004)
- Universiti Kebangsaan Malaysia
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
- Keywords
- aging, cognitive decline, cognitive impairment, DNA damage, protein oxidation, protein carbonyls, malondialdehyde, oxidative stress, biomarkers, Malay adults
- MeSH terms
- Adult, Aged, Aging, DNA Damage, Female, Humans, Male, Malondialdehyde, Middle Aged, Oxidative Stress, Cognitive Dysfunction
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