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Mucoadhesive chitosan and thiolated chitosan nanoparticles containing alpha mangostin for possible Colon-targeted delivery

Samprasit, Wipada, Opanasopit, Praneet, Chamsai, Benchawan·2021·Pharmaceutical Development and Technology
DOI 10.1080/10837450.2021.1873370
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Abstract

α-Mangostin-loaded mucoadhesive nanoparticles (NPs) were prepared for colon-targeted drug delivery against colorectal cancer cells using pH-dependent composite mucoadhesive NPs. Chitosan (CS) and thiolated chitosan (TCS) were used to form the NPs, following by genipin (GP) crosslinking and the surface modification by Eudragit ® L100 (L100). The particle size, morphologies and characteristics of NPs were observed. The α-mangostin loading and release patterns were investigated. In vitro mucoadhesive properties were examined by the wash-off method. In addition, the anti-tumour activity was tested on colorectal cancer cells. The results showed that NPs were slightly oblong in shape with particle size ranging between 300 and 900 nm. The small size of NPs was found with TCS and larger NPs were observed by GP and L100 process. However, GP and L100 provided an increase in α-mangostin loading, limited the release of α-mangostin in the upper gastrointestinal tract, and enhanced α-mangostin delivery to the colon. The TCS-based NPs with GP and L100 exhibited strong mucoadhesion to colon mucosa, more than uncoated-NPs and CS-based NPs. Moreover, NPs exhibited the anti-tumour activity. Therefore, the mucoadhesive TCS-based NPs could be a promising candidate for a controlled-release drug delivery system of α-mangostin to the colon.

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Metadata

Authors
Samprasit, W., Opanasopit, P., & Chamsai, B.
Venue
Pharmaceutical Development and Technology
Publisher
Informa UK Limited
Published
2021-01-17
Volume
26
Issue
3
Pages
362-372
ISSN
  • 1083-7450
  • 1097-9867
DOI
10.1080/10837450.2021.1873370
Cited by
50
References
1
Language
en
Funders
  • Research Institute of Rangsit University
  • Thailand Research Funds through the Research Team Promotion Grant

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