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REDUCTION OF CHROMIUM (VI) AND ITS RELATIONSHIP TO CARCINOGENESIS
Abstract
Although Cr(VI)-containing compounds are well-documented carcinogens, their mechanism of action is still not well understood. Recent studies have suggested that reduction of Cr(VI) to its lower oxidation states and related free-radical reactions play an important role in carcinogenesis. This article summarizes recent studies on (1) the reduction of Cr(VI) by ascorbate, diol- and thiol-containing molecules, certain flavoenzymes, cell organelles, intact cells, and whole animals; (2) free-radical production with emphasis on hydroxy radical generation via Fenton or Haber-Weiss type reactions; and (3) free-radical-induced cellular damage, such as DNA strand breaks, hydroxylation of 2'-deoxyguanosine, and activation of nuclear transcription factor kappa B.
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Citations
Cited by
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Valko, M., Izakovic, M., Mazur, M., Rhodes, C. J., & Telser, J. (2004) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000049134.69131.89 · Cited by 1,820
Metal-induced oxidative stress and signal transduction
Leonard, S. S., Harris, G. K., & Shi, X. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.09.010 · Cited by 663
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Rana, S. V. S. (2008) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2008.08.002 · Cited by 381
Leporatti, M. L., & Ivancheva, S. (2003) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(03)00047-3 · Cited by 323
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Metadata
- Authors
- Shi, X.
- Venue
- Journal of Toxicology and Environmental Health, Part B
- Publisher
- Informa UK Limited
- Published
- 1999-01
- Volume
- 2
- Issue
- 1
- Pages
- 87-104
- ISSN
- 1093-7404 (ISSN-L)
- 1521-6950
- OpenAlex
- W2058827343
- Cited by
- 306
- References
- 0
- FWCI
- 13.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shi, X. (1999). REDUCTION OF CHROMIUM (VI) AND ITS RELATIONSHIP TO CARCINOGENESIS. Journal of Toxicology and Environmental Health, Part B. https://doi.org/10.1080/109374099281241
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