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Efficacy and toxicity of adjuvant chemotherapy on colorectal cancer patients: how much influence from the genetics?

Duran, Goretti, Cruz, Raquel, Simoes, Ana Rita, Barros, Francisco, Giráldez, José María, Bernárdez, Beatriz, Anido, Urbano, Candamio, Sonia, López-López, Rafael, Carracedo, Ángel, Lamas, María Jesús·2020·Journal of Chemotherapy
DOI 10.1080/1120009x.2020.1764281
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Abstract

We studied the predictive value for response and toxicity of functional polymorphisms in genes involved in the oxaliplatin/fluorouracil pathway in colorectal cancer patients. One hundred and twenty-seven (127) patients were treated with curative intended surgery followed by adjuvant chemotherapy with FOLFOX (fluorouracil, leucovorin and oxaliplatin) regimen. The median age was 65.53 (27-80) years (66.9% male, 59.1% rectum). The median follow-up was 8.5 years (IQR, 4.1-9.4). At the end of follow-up, 59 patients (46.5%) had relapsed or died in the whole study population. We did find that XRCC1GG genotype is associated with a higher risk of developing haematologic toxicity. Furthermore, we report a significant association of the TS 3'UTR 6 bp/6 bp polymorphism and the XRCC1 rs25487 with a higher risk of developing anaemia and diarrhoea, respectively. On the other hand, none of the studied polymorphisms showed clinically relevant association with disease-free survival and overall survival or early failure to adjuvant FOLFOX therapy.

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Metadata

Authors
Duran, G., Cruz, R., Simoes, A. R., Barros, F., Giráldez, J. M., Bernárdez, B., Anido, U., Candamio, S., López-López, R., Carracedo, Á., & Lamas, M. J.
Venue
Journal of Chemotherapy
Publisher
Informa UK Limited
Published
2020-05-22
Volume
32
Issue
6
Pages
310-322
ISSN
  • 1120-009X
  • 1973-9478
DOI
10.1080/1120009x.2020.1764281
Cited by
12
References
0
Language
en
Update notices
correction (2020-07-10)
Funders
  • Ministerio de Ciencia e Innovación
  • Fundación Ramón Areces,
  • Fundación Barrie de la Maza

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