Anterior medial temporal lobe in human cognition: Memory for fear and the unexpected
Open accessAbstract
INTRODUCTION: To survive, an organism must remember occurrences of value in its environment. These include those that pose a threat to survival, novel or unexpected stimuli, or a general class of stimuli that represent punishment or reward. There is substantial evidence that memory for novel and emotionally salient events is enhanced relative to familiar or emotionally neutral events. METHODS: We present human functional magnetic resonance imaging (fMRI) experiments that address the neurobiological processes underlying upregulation of memory for novel or emotional events. RESULTS: Enhanced memory for novel or unexpected stimuli is mediated by anterior hippocampus, whereas increased memory for emotional stimuli is mediated by a beta-adrenergic-dependent modulation of amygdala-hippocampal interactions. We introduce a hypothesis that medial temporal connectivity with autonomic control centres may be central to this memory enhancement. CONCLUSION: Enhanced memory for stimuli that are of adaptive importance to survival is mediated by the anterior medial temporal lobe and effected via connections with the autonomic system.
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Modulation of amygdala-hippocampal connections is a key substrate of emotional memory.
“modulation of amygdala-hippocampal connections appears to be a key substrate of emotional memory (Strange and Dolan, 2006)”
From Affective Cognition and its Disruption in Mood Disorders (2011) · cites this paper as Strange and Dolan, 2006
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References 106 · Cited by 60
Research works printed but not linked: 1
- Rombouts S Machielsen W Witter M Barkhof F Lindeboom J Scheltens P Visual association encoding activates the medial temporal lobe: A functional magnetic resonance imaging study Hippocampus 1997 7 594 601 9443056
- Authors
- Strange, B. A., & Dolan, R. J.
- Affiliations
- National Hospital for Neurology and Neurosurgery (GB)
- Venue
- Cognitive Neuropsychiatry
- Publisher
- Informa UK Limited
- Published
- 2006-01
- Volume
- 11
- Issue
- 3
- Pages
- 198-218
- ISSN
- 1354-6805 (ISSN-L)
- 1464-0619
- PMC
- PMC2633117
- OpenAlex
- W2092608794
- Cited by
- 60
- References
- 106
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 2 · 2022: 11 · 2021: 3 · 2019: 4 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 1 · 2013: 1 · 2012: 3
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cognitive Neuropsychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Max Planck Digital Library (submittedVersion, other-oa)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Funders
- Wellcome Trust (078865)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- emotional memory, anterior hippocampus, beta-adrenergic modulation, autonomic nervous system, survival value, reward and punishment
- MeSH terms
- Adrenergic beta-Antagonists, Amygdala, Autonomic Nervous System, Cognition, Fear, Hippocampus, Humans, Memory, Propranolol, Mental Recall, Temporal Lobe
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