Evolocumab, a PCSK9 inhibitor, protects human endothelial cells against H 2 O 2 -induced oxidative stress

Safaeian, Leila; Mirian, Mina; Bahrizadeh, Shahryar

doi:10.1080/13813455.2020.1788605

Evolocumab, a PCSK9 inhibitor, protects human endothelial cells against H 2 O 2 -induced oxidative stress

Context Recent surveys have shown an association between proprotein convertase subtilisin/kexin type 9 (PCSK9) and oxidative stress. Objective In this investigation, the effect of evolocumab an anti-PCSK9 antibody was assessed against oxidative damage caused by hydrogen peroxide (H 2 O 2 ) in hum…