The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Therapeutic potential of naringin: an overview
Open accessAbstract
CONTEXT: Naringin is a natural flavanone glycoside that is found in the Chinese herbal medicines and citrus fruits. Studies have demonstrated that naringin possesses numerous biological and pharmacological properties, but few reviews of these studies have been performed. OBJECTIVE: The present review gathers the fragmented information available in the literature describing the extraction of naringin, its pharmacology and its controlled release formulations. Current research progress and the therapeutic potential of naringin are also discussed. METHODS: A literature survey for relevant information regarding the biological and pharmacological properties of naringin was conducted using Pubmed, Sciencedirect, MEDLINE, Springerlink and Google Scholar electronic databases from the year 2007-2015. RESULTS: Naringin modulates signalling pathways and interacts with signalling molecules and thus has a wide range of pharmacological activities, including anti-inflammatory, anti-cancer activities, as well as effects on bone regeneration, metabolic syndrome, oxidative stress, genetic damage and central nervous system (CNS) diseases. Information was gathered that showed the extraction of naringin can be improved using several modifications. There has been some progress in the development of controlled release formulations of naringin. CONCLUSION: Naringin is a promising candidate for further in vivo studies and clinical use. More detailed studies regarding its mechanism of action are required.
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1 retracted
Chen, F., Zhang, N., Ma, X., Huang, T., Shao, Y., Wu, C., & Wang, Q. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143868 · Cited by 44
RetractedBenavente-García, O., & Castillo, J. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf8006568 · Cited by 1,158 · cited 4×
“Although inflammation is a normal response to tissue injury, if uncontrolled, it can lead to chronic autoimmune diseases, and anti-inflammatory compounds may be needed to control the inflammatory response (Benavente-Garc ıa & Castillo 2008).”
BackgroundInfluentialChronic inflammation: importance of NOD2 and NALP3 in interleukin-1β generation
Ferrero-Miliani, L., Nielsen, O. H., Andersen, P. S., & Girardin, S. E. (2007) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2006.03261.x · Cited by 1,079
Alam, M. A., Subhan, N., Rahman, M. M., Uddin, S. J., Reza, H. M., & Sarker, S. D. (2014) · Advances in Nutrition · doi:10.3945/an.113.005603 · Cited by 788
Biological Properties of Citrus Flavonoids Pertaining to Cancer and Inflammation
Manthey, J., Guthrie, N., & Grohmann, K. (2001) · Current Medicinal Chemistry · doi:10.2174/0929867013373723 · Cited by 566
Mahmoud, A. M., Ashour, M. B., Abdel-Moneim, A., & Ahmed, O. M. (2012) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2012.06.001 · Cited by 374
Jäger, A. K., & Saaby, L. (2011) · Molecules · doi:10.3390/molecules16021471 · Cited by 330
Effects of epigallocatechin gallate and quercetin on oxidative damage to cellular DNA
Johnson, M. K., & Loo, G. (2000) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(99)00074-9 · Cited by 274
Preclinical Evidence for the Pharmacological Actions of Naringin: A Review
Bharti, S., Rani, N., Krishnamurthy, B., & Arya, D. (2014) · Planta Medica · doi:10.1055/s-0034-1368351 · Cited by 244
Alam, M., Kauter, K., & Brown, L. (2013) · Nutrients · doi:10.3390/nu5030637 · Cited by 214
Cited by
Naringin‐generated ROS promotes mitochondria‐mediated apoptosis in Candida albicans
Kim, H., & Lee, D. G. (2021) · IUBMB Life · doi:10.1002/iub.2476 · Cited by 44
Wu, B.-W., Guo, J.-D., Wu, M.-S., Liu, Y., Lu, M., Zhou, Y.-H., & Han, H.-W. (2020) · Epigenomics · doi:10.2217/epi-2019-0215 · Cited by 20
Metadata
- Authors
- Chen, R., Qi, Q.-L., Wang, M.-T., & Li, Q.-Y.
- Venue
- Pharmaceutical Biology
- Publisher
- Informa UK Limited
- Published
- 2016-08-26
- Volume
- 54
- Issue
- 12
- Pages
- 3203-3210
- ISSN
- 0925-1618 (ISSN-L)
- 1388-0209
- 1744-5116
- OpenAlex
- W2514937930
- Cited by
- 401
- References
- 53
- FWCI
- 7.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
