The DOI matches its Crossref record; 10 of the 11 references it cites were found in a registry or an index.
How low is too low? Postwash total motile sperm count effect on pregnancy outcomes in intrauterine insemination
Abstract
Intrauterine insemination (IUI) is a frequently used method to treat couples with infertility. There is evidence of decreased pregnancy rates with a total motile sperm count (TMSC) of less than 10 million, yet there remains to be a consensus on semen parameters for which to recommend IUI in the infertile population. The aim of this study was to determine a minimum threshold of TMSC on semen analysis to offer IUI cycles. This is a retrospective cohort study of all IUI cycles at a private practice infertility centre over four years. Our primary outcome of interest was the presence of clinical pregnancy after each cycle. A total of 999 women underwent 2,169 IUI cycles. The overall clinical pregnancy rate was 19.8% per cycle. During the first IUI each woman underwent, there was an increase in clinical pregnancy with increasing TMSC (OR 0.44) for TMSC ≤1 M to (OR 0.99) for TMSC 6-10 M, compared to TMSC >10 M. Among all IUI with a TMSC between 6 and 10 M, pregnancy outcomes improved with morphology >4% (OR 0.84), compared to morphology <4% (OR 0.25), relative to TMSC >10 M. Using receiver operating characteristic curves, we did not identify a TMSC threshold to offer IUI, although there was a positive correlation between TMSC and IUI success.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Citations
Cites
Fertility and infertility: Definition and epidemiology
Vander Borght, M., & Wyns, C. (2018) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2018.03.012 · Cited by 2,278
Thoma, M. E., McLain, A. C., Louis, J. F., King, R. B., Trumble, A. C., Sundaram, R., & Louis, G. M. B. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.11.037 · Cited by 739
Definitions of infertility and recurrent pregnancy loss: a committee opinion
(2020) · Fertility and Sterility · doi:10.1016/j.fertnstert.2019.11.025 · Cited by 639
Merviel, P., Heraud, M. H., Grenier, N., Lourdel, E., Sanguinet, P., & Copin, H. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.09.058 · Cited by 295
Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility
Diamond, M. P., Legro, R. S., Coutifaris, C., Alvero, R. J., Robinson, R. D., Casson, P. R., Christman, G. M., Ager, J. W., Huang, H., Hansen, K. R., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1414827 · Cited by 285
Infertility Workup for the Women’s Health Specialist
(2019) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000003271 · Cited by 265
Voorhis, B. J. V., Barnett, M. J., Sparks, A. E., Syrop, C. H., Rosenthal, G. E., & Dawson, J. D. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(00)01783-0 · Cited by 252
Processed total motile sperm count correlates with pregnancy outcome after intrauterine insemination
Miller, D. C., Hollenbeck, B. K., Smith, G. D., Randolph, J. F., Christman, G. M., Smith, Y. R., Lebovic, D. I., & Ohl, D. A. (2002) · Urology · doi:10.1016/s0090-4295(02)01773-9 · Cited by 141
Prewash total motile count is a poor predictor of live birth in intrauterine insemination cycles
Mankus, E. B., Holden, A. E. C., Seeker, P., Kampschmidt, J. C., McLaughlin, J. E., Schenken, R. S., & Knudtson, J. F. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.12.025 · Cited by 33
Stanhiser, J., Mersereau, J. E., Dock, D., Boylan, C. F., Caprell, H., Coward, R. M., Berger, D. S., & Fritz, M. A. (2020) · F&S Reports · doi:10.1016/j.xfre.2020.11.007 · Cited by 11
Research works printed but not linked: 2
- 10.1023/a:10225768316911 · DOI
- World Health Organization (1999). WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction Fourth Edition. https://www.aab.org/images/WHO%204th%20manual.pdf
Cited by
Sorted by citations
Yavuzcan, A., Yurtçu, E., Keyif, B., & Osmanlıoğlu, Ş. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm14010043 · Cited by 4
Dahan, M. H., Tan, S. L., Nair, S., & Isaacs, T. F. (2023) · PubMed Central · doi:10.22074/ijfs.2023.560766.1355 · Cited by 2
Габдулхаевич, Ф. Р., Pupykina, K. A., Шарафутдинова, Л. А., Fedorova, A., Hismatullina, Z. R., Garipova, M. I., Koroleva, E. F., Ямалеева, А. А., & Rendyuk, T. D. (2024) · Drug development & registration · doi:10.33380/2305-2066-2024-13-2-1677 · Cited by 2
Tang, Q., Yi, H., Chen, S., Zheng, Y., Wen, Y., & Yang, M. (2024) · International Journal of General Medicine · doi:10.2147/ijgm.s450912 · Cited by 1
Wan, B., Ma, N., Zhou, Z., Lu, W., & Fu, Y. (2026) · European journal of medical research · doi:10.1186/s40001-026-04474-x · Cited by 1
Optimal follicle size for hCG trigger in intrauterine insemination cycles: evidence from 2275 cases
Zhao, M., Ma, Y., & Pan, Y. L. (2026) · European journal of medical research · doi:10.1186/s40001-026-04381-1
Kabukçu, C., & Kılıç, D. (2026) · Pamukkale Medical Journal · doi:10.31362/patd.2017141
Metadata
- Authors
- Mathes, M., Kastrick, E., Sayles, H., & Gustin, S.
- Affiliations
- University of Nebraska Medical Center (US)
- Corresponding author
- Mathes, Melissa
- Venue
- Human Fertility
- Publisher
- Informa UK Limited
- Published
- 2022-11-10
- Volume
- 26
- Issue
- 5
- Pages
- 1108-1113
- ISSN
- 1464-7273 (ISSN-L)
- 1742-8149
- OpenAlex
- W4308774693
- Cited by
- 7
- References
- 11
- Citations by year
- 2026: 3 · 2024: 2 · 2023: 2
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Fertility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Keywords
- intrauterine insemination, total motile sperm count, semen analysis, clinical pregnancy rate, sperm morphology, infertility treatment
- MeSH terms
- Female, Humans, Infertility, Insemination, Artificial, Homologous, Male, Pregnancy, Pregnancy Outcome, Retrospective Studies, Semen, Sperm Count, Sperm Motility, Pregnancy Rate
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
