The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Stem cell therapy in amyotrophic lateral sclerosis: a methodological approach in humans
Abstract
INTRODUCTION: Recently it has been shown in animal models of amyotrophic lateral sclerosis (ALS) that stem cells significantly slow the progression of the disease and prolong survival. We have evaluated the feasibility and safety of a method of intraspinal cord implantation of autologous mesenchymal stem cells (MSCs) in a few well-monitored patients with ALS. METHOD: Bone marrow collection was performed according to the standard procedure by aspiration from the posterior iliac crest. Ex vivo expansion of mesenchymal stem cells was induced according to Pittenger's protocol. The cells were suspended in 2 ml of autologous cerebrospinal fluid and transplanted into the spinal cord by a micrometric pump injector. RESULTS: No patient manifested major adverse events such as respiratory failure or death. Minor adverse events were intercostal pain irradiation (4 patients) which was reversible after a mean period of three days after surgery, and leg sensory dysesthesia (5 patients) which was reversible after a mean period of six weeks after surgery. No modification of the spinal cord volume or other signs of abnormal cell proliferation were observed. CONCLUSIONS: Our results appear to demonstrate that the procedures of ex vivo expansion of autologous mesenchymal stem cells and of transplantation into the spinal cord of humans are safe and well tolerated by ALS patients.
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1 retracted
RETRACTED ARTICLE: Pluripotency of mesenchymal stem cells derived from adult marrow
Jiang, Y., Jahagirdar, B. N., Reinhardt, R. L., Schwartz, R. E., Keene, C. D., Ortiz-Gonzalez, X. R., Reyes, M., Lenvik, T., Lund, T., Blackstad, M., et al. (2002) · Nature · doi:10.1038/nature00870 · Cited by 5,518
RetractedMultilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
Adult rat and human bone marrow stromal cells differentiate into neurons
Woodbury, D., Schwarz, E. J., Prockop, D. J., & Black, I. B. (2000) · Journal of Neuroscience Research · doi:10.1002/1097-4547(20000815)61:4<364::aid-jnr2>3.0.co;2-c · Cited by 2,434
Transplantation of Embryonic Dopamine Neurons for Severe Parkinson's Disease
Freed, C. R., Greene, P. E., Breeze, R. E., Tsai, W.-Y., DuMouchel, W., Kao, R., Dillon, S., Winfield, H., Culver, S., Trojanowski, J. Q., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103083441002 · Cited by 2,366
Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion
Terada, N., Hamazaki, T., Oka, M., Hoki, M., Mastalerz, D. M., Nakano, Y., Meyer, E. M., Morel, L., Petersen, B. E., & Scott, E. W. (2002) · Nature · doi:10.1038/nature730 · Cited by 1,999
Adult Bone Marrow Stromal Cells Differentiate into Neural Cells in Vitro
Sanchez-Ramos, J., Song, S., Cardozo-Pelaez, F., Hazzi, C., Stedeford, T., Willing, A., Freeman, T. B., Saporta, S., Janssen, W., Patel, N., et al. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7389 · Cited by 1,562
McDonald, J. W., Liu, X.-Z., Qu, Y., Liu, S., Mickey, S. K., Turetsky, D., Gottlieb, D. I., & Choi, D. W. (1999) · Nature Medicine · doi:10.1038/70986 · Cited by 1,226
TRANSPLANTATION OF EMBRYONIC DOPAMINE NEURONS FOR SEVERE PARKINSON'S DISEASE
Reed, R., Reene, P. A. E. G., Reeze, R. O. E. B., Ei, W., Ouchel, W. I. D. U. M., Ao, R. I. K., Infield, W., Ulver, S. H. C., Rojanowski, J. O. Q. T., Idelberg, D. A. E., et al. (2001) · Cited by 1,001
Cell replacement therapies for central nervous system disorders
Björklund, A., & Lindvall, O. (2000) · Nature Neuroscience · doi:10.1038/75705 · Cited by 934
Zhao, L.-R., Duan, W.-M., Reyes, M., Keene, C. D., Verfaillie, C. M., & Low, W. C. (2002) · Experimental Neurology · doi:10.1006/exnr.2001.7853 · Cited by 823
Cited by
Mesenchymal Stem Cells as Therapeutics
Parekkadan, B., & Milwid, J. M. (2010) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-070909-105309 · Cited by 759
Mitchell, J., & Borasio, G. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60944-1 · Cited by 561
Kocaoemer, A., Kern, S., Klüter, H., & Bieback, K. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0627 · Cited by 414
Mesenchymal stem cell transplantation in amyotrophic lateral sclerosis: A Phase I clinical trial
Mazzini, L., Ferrero, I., Luparello, V., Rustichelli, D., Gunetti, M., Mareschi, K., Testa, L., Stecco, A., Tarletti, R., Miglioretti, M., et al. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2009.08.007 · Cited by 396
Self-citationVercelli, A., Mereuta, O. M., Garbossa, D., Muraca, G., Mareschi, K., Rustichelli, D., Ferrero, I., Mazzini, L., Madon, E., & Fagioli, F. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.05.016 · Cited by 309
Self-citation
Metadata
- Authors
- Mazzini, L., Fagioli, F., Boccaletti, R., Mareschi, K., Oliveri, G., Olivieri, C., Pastore, I., Marasso, R., & Madon, E.
- Venue
- Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders
- Publisher
- Informa UK Limited
- Published
- 2003-09
- Volume
- 4
- Issue
- 3
- Pages
- 158-161
- ISSN
- 1466-0822 (ISSN-L)
- OpenAlex
- W2123402756
- Cited by
- 256
- References
- 28
- FWCI
- 6.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mazzini, L., Fagioli, F., Boccaletti, R., Mareschi, K., Oliveri, G., Olivieri, C., Pastore, I., Marasso, R., & Madon, E. (2003). Stem cell therapy in amyotrophic lateral sclerosis: a methodological approach in humans. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. https://doi.org/10.1080/14660820310014653
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
