The effects of soy isoflavone on insulin sensitivity and adipocytokines in insulin resistant rats administered with high-fat diet
Abstract
The effects of soy isoflavone (SIF) on insulin sensitivity and adipocytokines in high-fat-diet-induced insulin resistant (IR) rats were studied. Male Sprague Dawley rats (n = 80) were randomly assigned into a basal diet fed group and high-fat diet fed group. The high-fat-diet-induced IR rats were assigned into IR model control group and three SIF-treated groups with different dosages. Thirty days later, the fasting blood glucose, insulin and adipocytokines in serum and mRNA expressions of adipocytokines in perirenal white adipose tissue were measured. The Homeostasis Model Assessment of IR was calculated. The administration of 450 mg kg(-1) d(-1) SIF decreased the body weights and depositions of visceral adipose tissue as well as improved insulin resistance in high-fat-diet-induced IR rats. The mechanisms were associated with SIF regulating the expression of adipocytokines, including adiponectin, leptin, resistin and TNF-alpha. SIF supplements may have favourable effects on insulin resistance in high-fat-diet-induced IR rats.
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The physiological effects of the compounds are consistent with phytoestrogenic activity.
“All these physiological effects are consistent with phytoestrogenic activity [32].”
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References 43 · Cited by 23
- Authors
- Zhang, H.-M., Chen, S.-W., Zhang, L.-S., & Feng, X.-F.
- Venue
- Natural Product Research
- Publisher
- Informa UK Limited
- Published
- 2008-12-15
- Volume
- 22
- Issue
- 18
- Pages
- 1637-1649
- ISSN
- 1478-6419 (ISSN-L)
- 1478-6427
- OpenAlex
- W2129338064
- Cited by
- 23
- References
- 43
- Citations by year
- 2026: 1 · 2024: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 1 · 2012: 1
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Natural Product Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wayne State University
- National Natural Science Foundation of China
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Keywords
- soy isoflavones, insulin resistance, high-fat diet, adipokines, adiponectin, leptin, resistin, TNF-α, visceral adipose tissue, insulin sensitivity, HOMA-IR, fasting blood glucose, body weight
- MeSH terms
- Animals, Dietary Fats, Disease Models, Animal, Hypoglycemic Agents, Insulin, Insulin Resistance, Isoflavones, Male, Glycine max, Rats, Sprague-Dawley, Rats, Adipokines
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