The DOI matches its Crossref record, with a small difference in title or year; 2 of the 2 references it cites were found in a registry or an index.
Effect of madecassoside and catalpol in amelioration of insulin sensitivity in pancreatic (INS-1E) β-cell line
Open accessAbstract
Currently, type 2 diabetes mellitus (T2D) has emerged as global burden disease. Herbal drugs with antidiabetic activities are attracting the attention. Madecassoside and catalpol are herbal compounds having strong antioxidant and glucose lowering activity. Madecassoside and catalpol were investigated for their effect on insulin sensitivity using pancreatic INS-1E cells. Cytotoxicity of these compounds was evaluated by MTT assay. Glucose-stimulated insulin secretion (GSIS) and expression of insulin signalling proteins were studied in presence of madecassoside and catalpol. Results revealed that madecassoside and catalpol enhanced the GSIS without cytotoxic effect. Madecassoside (30 µM) and catalpol (40 µM) increased the insulin secretion in response to high glucose (16.7 mM) stimulation. Subsequently, madecassoside and catalpol showed elevated expression of p-IRS-1, Akt, and p-Akt proteins. Madecassoside and catalpol after 24 h of incubation in pancreatic INS-1E cells with high glucose concentration (30 mM) ameliorated the insulin secretion.
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“Madecassoside improves insulin sensitivity in pancreatic cells to promote glucose‐stimulated insulin secretion (GSIS) and to enhance expression of insulin signalling proteins without any cytotoxic effects”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [129]
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Cites
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation
Gual, P., Le Marchand-Brustel, Y., & Tanti, J.-F. (2005) · Biochimie · doi:10.1016/j.biochi.2004.10.019 · Cited by 912 · cited 1×
“Studies reported that glucose stimulated insulin secretion activates p(Tyr608)-IRS1 and subsequent intracellular signal transduction pathway, suggesting the role of pIRS1 in the autocrine mechanism which regulates pancreatic b cells function (Gual et al. 2005).”
BackgroundLeibiger, B., Leibiger, I. B., Moede, T., Kemper, S., Kulkarni, R. N., Kahn, C. R., de Vargas, L. M., & Berggren, P.-O. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00203-9 · Cited by 267
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Cited by
Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review
Bandopadhyay, S., Mandal, S., Ghorai, M., Jha, N. K., Kumar, M., Radha, Ghosh, A., Proćków, J., Pérez de la Lastra, J. M., & Dey, A. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17635 · Cited by 220
Metadata
- Authors
- Elhassan, S. A. M., Candasamy, M., Ching, T. S., Heng, Y. K., & Bhattamisra, S. K.
- Affiliations
- IMU University (MY)
- Corresponding author
- Candasamy, Mayuren
- Bhattamisra, Subrat Kumar
- Venue
- Natural Product Research
- Publisher
- Informa UK Limited
- Published
- 2019-12-04
- Volume
- 35
- Issue
- 22
- Pages
- 4627-4631
- ISSN
- 1478-6419 (ISSN-L)
- 1478-6427
- OpenAlex
- W2992717626
- Cited by
- 13
- References
- 2
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 1 · 2021: 3 · 2020: 1
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- cc-by
- Locations
- Natural Product Research (publishedVersion)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Figshare (cc-by)
- Funders
- International Medical University
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- madecassoside, catalpol, insulin sensitivity, type 2 diabetes, INS-1E cells, pancreatic beta cells, glucose-stimulated insulin secretion, insulin signaling, IRS-1 phosphorylation, Akt phosphorylation, cytotoxicity
- MeSH terms
- Animals, Cell Line, Glucose, Insulin, Insulin Resistance, Triterpenes, Insulin-Secreting Cells, Rats, Iridoid Glucosides
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- The paper
- Elhassan, S. A. M., Candasamy, M., Ching, T. S., Heng, Y. K., & Bhattamisra, S. K. (2021). Effect of madecassoside and catalpol in amelioration of insulin sensitivity in pancreatic (INS-1E) β-cell line. Natural Product Research. https://doi.org/10.1080/14786419.2019.1696794
