Reactive Oxygen Species as Mediators of Cellular Senescence
Open accessAbstract
Aging has often been viewed as a random process arising from the accumulation of both genetic and epigenetic changes. Increasingly, the notion that aging is a stochastic process is being supplanted by the concept that maximum lifespan of an organism is tightly regulated. This knowledge has led to a growing overlap between classical signal transduction paradigms and the biology of aging. We review certain specific examples where these seemingly disparate disciplines intersect. In particular, we review the concept that intracellular reactive oxygen species function as signalling molecules and that oxidants play a central role as mediators of cellular senescence. IUBMB Life, 57: 277‐281, 2005
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DNA damage signaling is involved in the initiation of stress-induced premature senescence in response to acute cellular stresses, such as oxidative damage generated by ROS and oncogene activation.
“DNA damage signaling is also involved in the initiation of stress-induced premature senescence in response to acute cellular stresses, such as oxidative damage generated by ROS [117] and oncogene activation [69,70].”
From Mechanisms and Regulation of Cellular Senescence (2021) · cites this paper as [117]
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References 42 · Cited by 242
- Authors
- Colavitti, R., & Finkel, T.
- Affiliations
- National Institutes of Health (US)
- ORCID
- Finkel, Toren
- Venue
- IUBMB Life
- Publisher
- Wiley
- Published
- 2005-04
- Volume
- 57
- Issue
- 4-5
- Pages
- 277-281
- ISSN
- 1521-6543 (ISSN-L)
- 1521-6551
- OpenAlex
- W1971755855
- Cited by
- 242
- References
- 42
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 7 · 2023: 16 · 2022: 12 · 2021: 20 · 2020: 19 · 2019: 18 · 2018: 12 · 2017: 8 · 2016: 17 · 2015: 12 · 2014: 17 · 2013: 8 · 2012: 12
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- IUBMB Life (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- reactive oxygen species, cellular senescence, aging, signal transduction, maximum lifespan, epigenetic modifications, stochastic aging
- MeSH terms
- Animals, Free Radicals, Humans, Models, Biological, Oxygen, Transcription, Genetic, Signal Transduction, Oxidants, Cellular Senescence, Reactive Oxygen Species, Oxidative Stress, Telomerase, MAP Kinase Signaling System
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