The DOI matches its Crossref record.
In vitro biologic toxicity of native and surface‐modified silica and kaolin
Abstract
An in vitro study of the biologic responses of surface-modified and native silica and kaolin was made to provide comparative information on the suppression of cytotoxicity by pulmonary surfactant. The release of alveolar macrophage cytoplasmic enzyme, lactate dehydrogenase (LDH), and lysosomal enzymes beta-N-acetylglucosaminidase (beta-NAG) and beta-glucuronidase (beta-GLUC) and sheep blood-cell hemolysis were monitored as indicators of cell membrane damage and cytotoxicity. Surface modification of silica and kaolin with dipalmitoyl lecithin (DPL) resulted in complete abrogation of cytotoxicity of both minerals. These findings indicate that surface modification of minerals with different adsorption properties by pulmonary surfactant generally lessens their prompt adverse effects.
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In the citing paper
“But most importantly, these investigations have included the elucidation of the role of iron in these processes [335, 336] and also the importance of surface properties in the toxicity of particles and fibres with subsequent reduction of this toxicity through surface modification [321, 337].”
From Particle toxicology and health - where are we? (2019) · cites this paper as [321]
In the citing paper
“These have included once again size [315, 316] and also crystalline nature [317], adsorptive ability of alveolar and serum components as well benzo(a) pyrene [318–321], and dissolution and biodegradation of mineral fibres [322, 323].”
From Particle toxicology and health - where are we? (2019) · cites this paper as [321]
In the citing paper
“The decade between 1980 and 1990 produced an impressive number of investigations on the importance of the physicochemical properties of particles and fibres in producing toxicity and pathogenicity.”
From Particle toxicology and health - where are we? (2019) · cites this paper as [321]
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No references could be resolved yet.
Research works printed but not linked: 18
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Cited by
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Particle toxicology and health - where are we?
Riediker, M., Zink, D., Kreyling, W., Oberdörster, G., Elder, A., Graham, U., Lynch, I., Duschl, A., Ichihara, G., Ichihara, S., et al. (2019) · Particle and Fibre Toxicology · doi:10.1186/s12989-019-0302-8 · Cited by 237
Metadata
- Authors
- Wallace, W. E., Vallyathan, V., Keane, M. J., & Robinson, V.
- Venue
- Journal of Toxicology and Environmental Health
- Publisher
- Informa UK Limited
- Published
- 1985-01
- Volume
- 16
- Issue
- 3-4
- Pages
- 415-424
- ISSN
- 0098-4108
- Cited by
- 67
- References
- 0
- Language
- en
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- CoChat. (2026). Citation check: In vitro biologic toxicity of native and surface‐modified silica and kaolin. https://app.cochat.ai/papers/10.1080/15287398509530751
- The paper
- Wallace, W. E., Vallyathan, V., Keane, M. J., & Robinson, V. (1985). In vitro biologic toxicity of native and surface‐modified silica and kaolin. Journal of Toxicology and Environmental Health. https://doi.org/10.1080/15287398509530751
