The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Autophagy and apoptosis in liver injury
Open accessAbstract
Apoptosis is a primary characteristic in the pathogenesis of liver disease. Hepatic apoptosis is regulated by autophagic activity. However, mechanisms mediating their interaction remain to be determined. Basal level of autophagy ensures the physiological turnover of old and damaged organelles. Autophagy also is an adaptive response under stressful conditions. Autophagy can control cell fate through different cross-talk signals. A complex interplay between hepatic autophagy and apoptosis determines the degree of hepatic apoptosis and the progression of liver disease as demonstrated by pre-clinical models and clinical trials. This review summarizes recent advances on roles of autophagy that plays in pathophysiology of liver. The autophagic pathway can be a novel therapeutic target for liver disease.
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Citations
Cites
Autophagy in the Pathogenesis of Disease
Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069
Autophagy regulates lipid metabolism
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The role of autophagy during the early neonatal starvation period
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Impairment of starvation-induced and constitutive autophagy in Atg7 -deficient mice
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Self-consumption: the interplay of autophagy and apoptosis
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DRAM, a p53-Induced Modulator of Autophagy, Is Critical for Apoptosis
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Crosstalk between apoptosis.; necrosis and autophagy
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“Future studies may focus on the dynamic equilibrium among autophagy, apoptosis, and necrosis in the context of disease-related pathogenesis.(11,12) A good understanding of these relationships would be essential in the development of therapeutics targeting the autophagy pathway for the treatment of relevant diseases.”
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Cited by
Spaceflight Activates Autophagy Programs and the Proteasome in Mouse Liver
Blaber, E., Pecaut, M., & Jonscher, K. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102062 · Cited by 70
Lu, W., Mei, J., Yang, J., Wu, Z., Liu, J., Miao, P., Chen, Y., Wen, Z., Zhao, Z., Kong, H., et al. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117601 · Cited by 65
Metadata
- Authors
- Wang, K.
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2015-06-02
- Volume
- 14
- Issue
- 11
- Pages
- 1631-1642
- ISSN
- 1538-4101 (ISSN-L)
- 1551-4005
- OpenAlex
- W1854470074
- Cited by
- 363
- References
- 26
- FWCI
- 13.07
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
