Hsp90 inhibitors as senolytic drugs to extend healthy aging
Open accessAbstract
Aging is characterized by progressive decay of biological systems and although it is not considered a disease, it is one of the main risk factors for chronic diseases and many types of cancers. The accumulation of senescent cells in various tissues is thought to be a major factor contributing to aging and age-related diseases. Removal of senescent cells during aging by either genetic or therapeutic methods have led to an improvement of several age related disease in mice. In this preview, we highlight the significance of developing senotherapeutic approaches to specifically kill senescent cells (senolytics) or suppress the senescence-associated secretory phenotype (SASP) that drives sterile inflammation (senomorphics) associated with aging to extend healthspan and potentially lifespan. Also, we provide an overview of the senotherapeutic drugs identified to date. In particular, we discuss and expand upon the recent identification of inhibitors of the HSP90 co-chaperone as a new class of senolytics.
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Additional senolytics such as HSP90 inhibitors and piperlongumine have been shown to act selectively on senescent cells.
“Other senolytics, including HSP90 inhibitors213,214 and piperlongumine215,216, have also been demonstrated to be selective towards senescent cells.”
From Cellular senescence in ageing: from mechanisms to therapeutic opportunities (2021) · cites this paper as [213]
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References 122 · Cited by 92
Research works printed but not linked: 3
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- Authors
- Fuhrmann-Stroissnigg, H., Niedernhofer, L. J., & Robbins, P. D.
- Affiliations
- Department of Molecular Medicine and The Center on Aging, The Scripps Research Institute, Jupiter, FL, USA
- Scripps Research Institute (US)
- Corresponding author
- Robbins, Paul D.
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2018-05-03
- Volume
- 17
- Issue
- 9
- Pages
- 1048-1055
- ISSN
- 1538-4101 (ISSN-L)
- 1551-4005
- PMC
- PMC6110594
- OpenAlex
- W2806968602
- Cited by
- 92
- References
- 122
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 12 · 2023: 10 · 2022: 17 · 2021: 13 · 2020: 15 · 2019: 5 · 2018: 2
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cell Cycle (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG043376)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Keywords
- Hsp90 inhibitors, senolytics, senescence, senomorphics, senescence-associated secretory phenotype, sterile inflammation, healthy aging, healthspan, lifespan extension, senotherapeutics, Hsp90 co-chaperone
- MeSH terms
- Dasatinib, Healthy Aging, Aging, Animals, Antioxidants, Drug Therapy, Combination, Humans, Quercetin, Cellular Senescence, Apoptosis, HSP90 Heat-Shock Proteins, Protein Kinase Inhibitors, Mice, Idiopathic Pulmonary Fibrosis, Drug Discovery
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