Noncatalytic Functions of IPMK Are Essential for Activation of Autophagy and Liver Regeneration
Open accessAbstract
Macroautophagy/autophagy plays important roles in health and disease, but mechanisms of its activation are unclear. Recently we established IPMK (inositol polyphosphate multikinase) as a physiological determinant of autophagy independent of its catalytic activity. Two signaling axes, IPMK-AMPK-SIRT1 and IPMK-AMPK-ULK1, appear to mediate the influence of IPMK on autophagy. IPMK enhances autophagy-related transcription by stimulating AMPK-dependent SIRT1 activation, which mediates the deacetylation of histone 4 lysine 16. Furthermore, direct binding of IPMK to ULK and AMPK forms a ternary complex that facilitates AMPK-dependent ULK phosphorylation. Deletion of Ipmk virtually abolishes lipophagy, promotes liver damage and impairs hepatocyte regeneration. Our study establishes the importance of IPMK in regulation of autophagy and as a drug target for autophagy-related diseases.
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IPMK depletion impairs autophagy activation in both yeast and mammalian cells.
“IPMK depletion impairs autophagy activation in both yeast [64,65] and mammalian cells [14,82].”
From From Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease (2025) · cites this paper as [82]
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- Guha P, Tyagi R, Chowdhury S, et al. IPMK mediates activation of ULK signaling and transcriptional regulation of autophagy linked to liver inflammation and regeneration. Cell Rep. 2019 Mar 5;26(10):2692-2703.e7. Figure
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Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,622 · see citing works
Self-citationFrom Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease
Mishra, S. H., Chatterjee, S., Viera-Preval, L., & Guha, P. (2025) · Biomolecules · doi:10.3390/biom15091266 · Cited by 1 · see citing works
“IPMK depletion impairs autophagy activation in both yeast [64,65] and mammalian cells [14,82].”
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- Authors
- Guha, P., & Snyder, S. H.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Guha, Prasun
- Snyder, Solomon H
- Venue
- Autophagy
- Publisher
- Informa UK Limited
- Published
- 2019-05-21
- Volume
- 15
- Issue
- 8
- Pages
- 1473-1474
- ISSN
- 1554-8627 (ISSN-L)
- 1554-8635
- PMC
- PMC6613895
- OpenAlex
- W2943848663
- Cited by
- 18
- References
- 0
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 2
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Autophagy (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (DA000266)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- inositol polyphosphate multikinase, autophagy activation, liver regeneration, AMPK, SIRT1, ULK1, lipophagy, histone H4 deacetylation, hepatocyte injury, autophagy-related diseases
- MeSH terms
- Acetylation, Animals, Autophagy, Enzyme Activation, Histones, Humans, Liver Regeneration, Lysine, Models, Biological, Phosphotransferases (Alcohol Group Acceptor), Biocatalysis, AMP-Activated Protein Kinases
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