Characterising Phospholipids and Free Fatty Acids in Patients with Schizophrenia: A Case-Control Study
Abstract
OBJECTIVES: Previous studies have indicated that schizophrenia (SCZ) is linked to abnormal phospholipid and fatty acid metabolism. However, comprehensive analysis of phospholipids and free fatty acids (FFAs) for SCZ is very limited. Herein, we sought to compare serum levels of phospholipids and FFAs between patients with SCZ and healthy controls (HCs). METHODS: One hundred and nineteen SCZ patients and 109 HCs were enrolled in the study. The levels of 177 phospholipids and FFAs were measured in serum samples using a targeted liquid chromatography-mass spectrometry (LC-MS)-based platform. RESULTS: One hundred and ten metabolites, including 16 FFAs, 25 phosphatidylcholines, 23 lysophosphatidylcholines, 11 phosphatidylcholine plasmalogens, 7 phosphatidylethanolamines, 9 lysophosphatidylethanolamines, 6 phosphatidylethanolamine plasmalogens, and 13 sphingomyelins, were observed to be significantly altered in SCZ patients compared to HCs. These disturbances may represent underlying pathophysiology, including but not limited to altered activity of phospholipases and acyltransferases, increased oxidative stress, dysfunctional oligodendrocyte glycosynapses, and elevated lipid mobilisation and β-oxidation. CONCLUSIONS: Our findings suggest that complex lipid profile abnormalities are associated with SCZ. This study may contribute to investigating the role of phospholipid and FFA alterations in the pathoetiology of SCZ.
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Nine studies evaluated broad panels of different lipid markers in patients with SCZ and detected statistical differences in fatty acyls, sterols, glycerolipids, sphingolipids, glycerophospholipids, and products of lipid metabolism.
“Nine studies evaluated the broad panels of different lipid markers in patients with SCZ [31,34,40,41,42,43,44,45,46] and detected statistical differences in the following lipid classes: fatty acyls, sterols, glycerolipids, sphingolipids, glycerophospholipids, and products of lipid metabolism.”
From Lipids in Psychiatric Disorders: Functional and Potential Diagnostic Role as Blood Biomarkers (2024) · cites this paper as [45]
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References 57 · Cited by 26
- Authors
- Wang, D., Sun, X., Maziade, M., Mao, W., Zhang, C., Wang, J., & Cao, B.
- Affiliations
- Peking University (CN)
- Université Laval (CA)
- Institute of Blood Transfusion, Chongqing Blood Center, Chongqing, P. R. China
- Psychiatric Department, Weifang Mental Health Center, Weifang, P. R. China
- Southwest University (CN)
- Corresponding author
- Wang, Jingyu
- Cao, Bing
- Venue
- The World Journal of Biological Psychiatry
- Publisher
- Informa UK Limited
- Published
- 2020-07-17
- Volume
- 22
- Issue
- 3
- Pages
- 161-174
- ISSN
- 1562-2975 (ISSN-L)
- 1814-1412
- OpenAlex
- W3042505038
- Cited by
- 26
- References
- 57
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 10 · 2023: 4 · 2022: 4 · 2021: 2 · 2020: 1
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The World Journal of Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Peking University Health Science Centre Medical Cross Disciplinary Fund (BMU20140435)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- schizophrenia, phospholipids, free fatty acids, lipid profile, phosphatidylcholine, lysophosphatidylcholine, phosphatidylethanolamine, sphingomyelin, lipid metabolism, oxidative stress, phospholipase activity, acyltransferase, lipid mobilization, fatty acid beta-oxidation
- MeSH terms
- Chromatography, Liquid, Fatty Acids, Nonesterified, Humans, Schizophrenia, Case-Control Studies, Lipid Metabolism
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